SLC16A3 - solute carrier family 16 member 3 Gene

Also Known as MCT3; MCT4; MCT 3; MCT 4; MCT-3; MCT-4

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 9123

About SLC16A3

Cytogenetic location: 17q25.3 Genomic coordinates (GRCh38): 17:82,217,934-82,240,086 (from NCBI)

This gene has 19 transcripts (splice variants), 298 orthologues and 13 paralogues. Broad expression in placenta (RPKM 10.2), appendix (RPKM 8.8) and 22 other tissues.

Summary

Lactic acid and pyruvate transport across plasma membranes is catalyzed by members of the proton-linked Monocarboxylate Transporter (MCT) family, which has been designated solute carrier family-16. Each MCT appears to have slightly different substrate and inhibitor specificities and transport kinetics, which are related to the metabolic requirements of the tissues in which it is found. The MCTs, which include MCT1 (SLC16A1; MIM 600682) and MCT2 (SLC16A7; MIM 603654), are characterized by 12 predicted transmembrane domains (Price et al., 1998 [PubMed 9425115]).[supplied by OMIM, Mar 2008]

SLC16A3 Products (6)

mRNA Protein Name
NM_001042422.3 NP_001035887.1 monocarboxylate transporter 4
NM_001042423.3 NP_001035888.1 monocarboxylate transporter 4
NM_001206950.2 NP_001193879.1 monocarboxylate transporter 4
NM_001206951.2 NP_001193880.1 monocarboxylate transporter 4
NM_001206952.2 NP_001193881.1 monocarboxylate transporter 4
NM_004207.4 NP_004198.1 monocarboxylate transporter 4

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Verweise Source
enables lactate:proton symporter activity IDA
IDA: Inferred from direct assay
11101640 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
10921872 GOA
enables pyruvate transmembrane transporter activity IDA
IDA: Inferred from direct assay
31719150 GOA
Biological Process GO Annotation Evidence Verweise Source
involved in lactate transmembrane transport IDA
IDA: Inferred from direct assay
11101640 GOA
involved in pyruvate transmembrane transport IDA
IDA: Inferred from direct assay
31719150 GOA
Cellular Component GO Annotation Evidence Verweise Source
located in apical plasma membrane IDA
IDA: Inferred from direct assay
31791063 GOA
located in basolateral plasma membrane IDA
IDA: Inferred from direct assay
21199217 GOA
located in lateral plasma membrane IDA
IDA: Inferred from direct assay
26854723 GOA
located in plasma membrane IDA
IDA: Inferred from direct assay
10921872 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SLC16A3 Protein Structure

MFS_1

MFS_1: Major Facilitator Superfamily (28 - 371)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 465 a.a.
Protein Preferred Names Protein Names

monocarboxylate transporter 4

  • monocarboxylate transporter 3

SLC16A3 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Verweise
Intra
SLC16A3 O15427 FAM9B Homo sapiens Q8IZU0
Validated Y2H
25416956
Intra
SLC16A3 O15427 FAM9B Homo sapiens Q8IZU0
Y2H Prey Pooling
25416956
Intra
SLC16A3 O15427 NR2C2AP Homo sapiens Q86WQ0
Validated Y2H
25416956
Intra
SLC16A3 O15427 NR2C2AP Homo sapiens Q86WQ0
Y2H Array
25416956
Intra
SLC16A3 O15427 HDAC7 Homo sapiens Q8WUI4-6
Validated Y2H
32296183
Intra
SLC16A3 O15427 HPCA Homo sapiens P84074
Validated Y2H
32296183
Intra
SLC16A3 O15427 HPCA Homo sapiens P84074
Y2H Array
32296183
Intra
SLC16A3 O15427 HPCA Homo sapiens P84074
Y2H Prey Pooling
32296183
Intra
SLC16A3 O15427 GJA8 Homo sapiens P48165
Validated Y2H
32296183
Intra
SLC16A3 O15427 GJA8 Homo sapiens P48165
Y2H Array
32296183
Intra
SLC16A3 O15427 GJA8 Homo sapiens P48165
Y2H Prey Pooling
32296183
Intra
SLC16A3 O15427 UBQLN1 Homo sapiens Q9UMX0
Y2H Array
32296183
Intra
SLC16A3 O15427 UBQLN1 Homo sapiens Q9UMX0
Validated Y2H
32296183
Intra
SLC16A3 O15427 UBQLN1 Homo sapiens Q9UMX0
Y2H Prey Pooling
32296183
Intra
SLC16A3 O15427 BANP Homo sapiens Q8N9N5
Y2H Prey Pooling
25416956
Intra
SLC16A3 O15427 BANP Homo sapiens Q8N9N5
Validated Y2H
25416956
Intra
SLC16A3 O15427 UBQLN2 Homo sapiens Q9UHD9
Y2H Array
32296183
Intra
SLC16A3 O15427 UBQLN2 Homo sapiens Q9UHD9
Validated Y2H
32296183
Intra
SLC16A3 O15427 UBQLN2 Homo sapiens Q9UHD9
Y2H Prey Pooling
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

SLC16A3 Antibodies

Art. -Nr. Produktname Anwendung Reactivity
HY-P87073 SLC16A3/MCT 4 Antibody (YA6766) WB, IHC-P, ICC/IF, FC, mIHC Human, Monkey

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-132301 MSC-4381 Inhibitor 98.89% Unkown
HY-RS13025 SLC16A3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17673 Slc16a3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-182416 slCeMM1 Inhibitor / Unkown
HY-RS24134 Slc16a3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus SLC16A3 MGD MGI:1933438
Canis familiaris SLC16A3 VGNC VGNC:46242
Bos taurus SLC16A3 VGNC VGNC:34689
Macaca mulatta SLC16A3 VGNC VGNC:77397
Rattus norvegicus SLC16A3 RGD RGD:620603
Felis catus SLC16A3 VGNC VGNC:65210
Others SLC16A3 NCBI