GPR84 antagonist 2
Based on 1 Customer Validation
GPR84 antagonist 2 (compound 33) is a potent, selective, and orally active GPR84 antagonist (IC50=8.95 nM). GPR84 antagonist 2 shows improved potency in the calcium mobilization assay and the ability to inhibit the chemotaxis of neutrophils and macrophages upon GPR84 activation. GPR84 antagonist 2 has the potential for the research of ulcerative colitis.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- Reinheit : 99.06%
- CAS. Nr.: 2244269-74-5
- Formel: C28H16Cl2NaO4PS2
- Molecular Weight:605.42
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Speicherung:
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biologische Aktivität
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Chemical Information
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Lösungsmittel & Löslichkeit
- Protokoll
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
Biologische Aktivität
Beschreibung
Chemical Information
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CAS. Nr. 2244269-74-5
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Appearance Solid
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Molecular Weight 605.42
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Formel C28H16Cl2NaO4PS2
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Color Off-white to light yellow
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SMILES
O=P(OC1=CC2=C(SC3=C1C=CC=C3)C=CC=C2Cl)(OC4=CC5=C(SC6=C4C=CC=C6)C=CC=C5Cl)O[Na]
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Lösungsmittel & Löslichkeit
In Vitro:
DMSO : 125 mg/mL (206.47 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Working solution concentration: 0.22 mg/mL
Reinheit & Dokumentation
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Data Sheet (278 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
Verweise
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.6517 mL | 8.2587 mL | 16.5175 mL | 41.2936 mL |
| 5 mM | 0.3303 mL | 1.6517 mL | 3.3035 mL | 8.2587 mL | |
| 10 mM | 0.1652 mL | 0.8259 mL | 1.6517 mL | 4.1294 mL | |
| 15 mM | 0.1101 mL | 0.5506 mL | 1.1012 mL | 2.7529 mL | |
| 20 mM | 0.0826 mL | 0.4129 mL | 0.8259 mL | 2.0647 mL | |
| 25 mM | 0.0661 mL | 0.3303 mL | 0.6607 mL | 1.6517 mL | |
| 30 mM | 0.0551 mL | 0.2753 mL | 0.5506 mL | 1.3765 mL | |
| 40 mM | 0.0413 mL | 0.2065 mL | 0.4129 mL | 1.0323 mL | |
| 50 mM | 0.0330 mL | 0.1652 mL | 0.3303 mL | 0.8259 mL | |
| 60 mM | 0.0275 mL | 0.1376 mL | 0.2753 mL | 0.6882 mL | |
| 80 mM | 0.0206 mL | 0.1032 mL | 0.2065 mL | 0.5162 mL | |
| 100 mM | 0.0165 mL | 0.0826 mL | 0.1652 mL | 0.4129 mL |
GPR84 antagonist 2 Related Classifications
HY-145697 Related Classifications
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