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Art. -Nr.: HY-151806

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HadAB-IN-1

HadAB-IN-1 is a potent HadAB inhibitor. HadAB-IN-1 inhibits HadAB enzyme complexes activity with an IC₅₀ value of 0.03 μM. HadAB-IN-1 also affects mycolic acid biosynthesis in Mycobacterium tuberculosis (Mtb). HadAB-IN-1 can be used for the research of tuberculosis (TB).

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

CAS. Nr.: 1097120-47-2
Formel: C₁₉H₁₇BrClN₃O₃S
Molecular Weight:482.78

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (270 KB)

HadAB-IN-1 Chemical Structure

CAS. Nr.: 1097120-47-2

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- Cellular Effect
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target

IC50: 0.03 μM (HadAB enzyme complexes); MIC50: 4.7 μM (Mtb)^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
HepG2	IC₅₀	>50 μM Compound: 1	Cytotoxicity against human HepG2 cells under galactose containing medium Cytotoxicity against human HepG2 cells under galactose containing medium	[PMID: 34414766]
HepG2	IC₅₀	>50 μM Compound: 1	Cytotoxicity against human HepG2 cells under glucose containing medium Cytotoxicity against human HepG2 cells under glucose containing medium	[PMID: 34414766]

In Vitro

HadAB-IN-1has inhibition activity for HadAB enzyme complexes with an IC₅₀value of 0.03 μM^[1].
HadAB-IN-1 can inhibit Mycobacterium tuberculosis (Mtb) with an MIC₅₀value of 4.7 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS. Nr. 1097120-47-2
Molecular Weight 482.78
Formel C₁₉H₁₇BrClN₃O₃S
SMILES

CS(=O)(NC(CCC1=CN(N=C1C2=CC=C(C=C2)Cl)C3=CC=C(C=C3)Br)=O)=O
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (270 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Vinayak Singh, et al. 1,3-Diarylpyrazolyl-acylsulfonamides Target HadAB/BC Complex in Mycobacterium tuberculosis. ACS Infect Dis. 2022 Nov 11;8(11):2315-2326. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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