HSL-IN-3
Based on 1 publication(s) in Google Scholar
HSL-IN-3 is a HSL inhibitor. HSL-IN-3 serves as an important intermediate for the synthesis of PARP-1 inhibitors. HSL-IN-3 can be used in studies related to lipid metabolism.
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- Reinheit: 98.0%
- CAS. Nr.: 346656-34-6
- Formel: C14H19BO4
- Molecular Weight:262.11
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Speicherung:Pure form -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biologische Aktivität
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Chemical Information
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Lösungsmittel & Löslichkeit
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
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Metabolism/Protease Compound Library
HY-L012
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Covalent Screening Library
HY-L036
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Targeted Diversity Library
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Publications Citing Use of MedChemExpress (MCE) HSL-IN-3
More
Biologische Aktivität
HSL[1].
Chemical Information
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CAS. Nr. 346656-34-6
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Appearance Liquid (Density: 1.091±0.10 g/cm3)
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Molecular Weight 262.11
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Formel C14H19BO4
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Color Colorless to light yellow
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SMILES
O=C(OCC)C1=CC=CC=C1B2OCC(C)(C)CO2
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Pure form -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (1)
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Journal Impact Factor
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Most Recent
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EMBO J
Rab2A-mediated Golgi-lipid droplet interactions support very-low-density lipoprotein secretion in hepatocytes. [Abstract]2024 Dec;43(24):6383-6409. PMID: 39496977
Lösungsmittel & Löslichkeit
DMSO : 100 mg/mL (381.52 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.08 mg/mL (7.94 mM); Clear solution
This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.08 mg/mL (7.94 mM); Clear solution
This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Reinheit & Dokumentation
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Data Sheet (278 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
Verweise
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.8152 mL | 19.0760 mL | 38.1519 mL | 95.3798 mL |
| 5 mM | 0.7630 mL | 3.8152 mL | 7.6304 mL | 19.0760 mL | |
| 10 mM | 0.3815 mL | 1.9076 mL | 3.8152 mL | 9.5380 mL | |
| 15 mM | 0.2543 mL | 1.2717 mL | 2.5435 mL | 6.3587 mL | |
| 20 mM | 0.1908 mL | 0.9538 mL | 1.9076 mL | 4.7690 mL | |
| 25 mM | 0.1526 mL | 0.7630 mL | 1.5261 mL | 3.8152 mL | |
| 30 mM | 0.1272 mL | 0.6359 mL | 1.2717 mL | 3.1793 mL | |
| 40 mM | 0.0954 mL | 0.4769 mL | 0.9538 mL | 2.3845 mL | |
| 50 mM | 0.0763 mL | 0.3815 mL | 0.7630 mL | 1.9076 mL | |
| 60 mM | 0.0636 mL | 0.3179 mL | 0.6359 mL | 1.5897 mL | |
| 80 mM | 0.0477 mL | 0.2384 mL | 0.4769 mL | 1.1922 mL | |
| 100 mM | 0.0382 mL | 0.1908 mL | 0.3815 mL | 0.9538 mL |
HSL-IN-3 Related Classifications
HY-23524 Related Classifications
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