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Art. -Nr.: HY-184028

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IDO1-IN-37

IDO1/TDO-IN-13 (Compound 40) is a selective, non-competitive IDO1 inhibitor with an IC₅₀ of 0.106 μM against IDO1. IDO1/TDO-IN-13 is applicable to the research of inflammatory diseases.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

CAS. Nr.: 3117126-69-6
Formel: C₁₃H₆Cl₂FNO₂S
Molecular Weight:330.16

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

IDO1-IN-37 Chemical Structure

CAS. Nr.: 3117126-69-6

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
Chemical Information
Protokoll (1)
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target

^[1]

IDO1

0.106 μM (IC₅₀)

Alle Indoleamine 2,3-Dioxygenase (IDO) Isoform-spezifische Produkte anzeigen :

In Vitro

IDO1/TDO-IN-13 (45 min) potently inhibits recombinant IDO1 with an IC₅₀ of 0.106 μM; it also inhibits recombinant TDO2 with an IC₅₀ of 6.91 μM^[1].
IDO1/TDO-IN-13 (48 h) inhibits IDO1 activity in IFN-γ-stimulated BxPC-3 cells, with an IC₅₀ of 5.09 μM^[1].
IDO1/TDO-IN-13 (0-1.0 μM; 45 min) acts as a non-competitive inhibitor of recombinant IDO1 against D-tryptophan (HY-W012479)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.

Chemical Information

CAS. Nr. 3117126-69-6
Molecular Weight 330.16
Formel C₁₃H₆Cl₂FNO₂S
SMILES

ClC1=CC=C(C=C1)S(C2=NC3=C(O2)C=C(Cl)C(F)=C3)=O
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Protokoll

All Cell Biology

Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. Wang Y, et al. Taking advantage of the interaction between the sulfoxide and heme cofactor to develop indoleamine 2, 3-dioxygenase 1 inhibitors. Bioorg Chem. 2024;148:107426. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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