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Art. -Nr.: HY-116139

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Isoxaflutole

(Synonyms: Merlin; RP-201772)

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Isoxaflutole (Merlin) is the inhibitor for HPPD that blocks benzoquinone biosynthesis, and results in the bleaching of weeds. Isoxaflutole can be used as herbicide.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

Reinheit: 98.79%
CAS. Nr.: 141112-29-0
Formel: C₁₅H₁₂F₃NO₄S
Molecular Weight:359.32

Speicherung:

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Isoxaflutole Chemical Structure

CAS. Nr.: 141112-29-0

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Biologische Aktivität
- Beschreibung
- In Vitro
- In Vivo
- Clinical Trial
Chemical Information
Lösungsmittel & Löslichkeit
- In Vitro
Reinheit & Dokumentation
Verweise
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

Isoxaflutole (Merlin) is the inhibitor for HPPD that blocks benzoquinone biosynthesis, and results in the bleaching of weeds. Isoxaflutole can be used as herbicide^[1]^[2].

In Vitro

Isoxaflutole is a herbicide to control broadleaf weeds and grass weeds, and can be used for a pre-emergence control of broadleaf and grass weeds in corn and sugarcane^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Isoxaflutole (0-1000 mg/kg, po) exhibits chronic toxicity in rats and mice, causes pathological changes in organs such as liver and thyroid, such as hepatocyte hypertrophy and thyroid follicular hyperplasia under long-term exposure. Isoxaflutole increases the incidence of liver tumors in rats and mice. Isoxaflutole exhibits no significant toxic effects on the reproductive system of rats, but may affect embryonic development at high doses^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial

NCT Number	Sponsor	Condition	Start Date	Phase A549
NCT01329991	Plexxikon\|		2011-05	PHASE1

Chemical Information

CAS. Nr. 141112-29-0
Appearance Solid
Molecular Weight 359.32
Formel C₁₅H₁₂F₃NO₄S
Color White to off-white
SMILES

O=C(C1=CC=C(C=C1S(=O)(C)=O)C(F)(F)F)C2=C(ON=C2)C3CC3
Synonyms

Merlin; RP-201772
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Lösungsmittel & Löslichkeit

In Vitro:

DMSO : 100 mg/mL (278.30 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H₂O : < 0.1 mg/mL (insoluble)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

2.7830 mL

13.9152 mL

27.8303 mL

5 mM

0.5566 mL

2.7830 mL

5.5661 mL

10 mM

0.2783 mL

1.3915 mL

2.7830 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (281 KB)
SDS (623 KB)
- English - EN (623 KB)
- Français - FR (623 KB)
- Deutsch - DE (623 KB)
- Norwegian - NO (623 KB)
- Español - ES (623 KB)
- Swedish - SV (623 KB)
- Italian - IT (623 KB)
- Korean - KR (623 KB)
- Portuguese - PT (623 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Pallett KE, et al., Isoxaflutole: the background to its discovery and the basis of its herbicidal properties. Pest Manag Sci. 2001 Feb;57(2):133-42. [Content Brief]

[2]. Shah P V, et al., First draft prepared by PV Shah1 and Roland Alfred Solecki2 Office of Pesticide Programs, Environmental Protection Agency, Washington, DC, United States of America (USA) 2 Federal Institute for Risk Assessment, Berlin, Germany[J].

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	2.7830 mL	13.9152 mL	27.8303 mL	69.5759 mL
	5 mM	0.5566 mL	2.7830 mL	5.5661 mL	13.9152 mL
	10 mM	0.2783 mL	1.3915 mL	2.7830 mL	6.9576 mL
	15 mM	0.1855 mL	0.9277 mL	1.8554 mL	4.6384 mL
	20 mM	0.1392 mL	0.6958 mL	1.3915 mL	3.4788 mL
	25 mM	0.1113 mL	0.5566 mL	1.1132 mL	2.7830 mL
	30 mM	0.0928 mL	0.4638 mL	0.9277 mL	2.3192 mL
	40 mM	0.0696 mL	0.3479 mL	0.6958 mL	1.7394 mL
	50 mM	0.0557 mL	0.2783 mL	0.5566 mL	1.3915 mL
	60 mM	0.0464 mL	0.2319 mL	0.4638 mL	1.1596 mL
	80 mM	0.0348 mL	0.1739 mL	0.3479 mL	0.8697 mL
	100 mM	0.0278 mL	0.1392 mL	0.2783 mL	0.6958 mL

Keywords

MOQ

Minimum order quantity

100 mg

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Biologische Aktivität
- Beschreibung
- In Vitro
- In Vivo
- Clinical Trial
Chemical Information
Lösungsmittel & Löslichkeit
- In Vitro
Reinheit & Dokumentation
Verweise

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Isoxaflutole

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Pesticide Compound Library

High-Throughput Bioactive Compound Library

Mass Spectrometry Human Metabolite Library

Environmental Pollutant Compound Library

Biologische Aktivität

Chemical Information

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

Isoxaflutole

Metabolism/Protease Compound Library

Clinical Compound Library

Drug Repurposing Compound Library

Rare Diseases Drug Library

Human Metabolite Library

Metabolic Enzyme Compound Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Drug Repurposing Compound Library Plus

Clinical Compound Library Plus

Bioactive Compound Library

Pesticide Compound Library

High-Throughput Bioactive Compound Library

Mass Spectrometry Human Metabolite Library

Environmental Pollutant Compound Library

Biologische Aktivität

Chemical Information

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

Isoxaflutole Related Classifications

HY-116139 Related Classifications