LSD1-UM-109
LSD1-UM-109 is a ighly potent and reversible LSD1 inhibitor with an IC50 of 3.1 nM. LSD1-UM-109 inhibits cell growth with IC50 values of 0.6 nM in the MV4;11 acute leukemia cell line and 1.1 nM in the H1417 small-cell lung cancer cell line.
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- CAS. Nr.: 2252446-26-5
- Formel: C29H27FN6
- Molecular Weight:478.56
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Biologische Aktivität
Beschreibung
IC50 & Target
[1]|
LSD1 3.1 nM (IC50) |
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| MOLM-13 | IC50 |
31 nM
Compound: 46; LSD1-UM-109
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Antiproliferative activity against human MOLM-13 cells assessed as cell growth inhibition incubated for 7 days by WST-8 assay
Antiproliferative activity against human MOLM-13 cells assessed as cell growth inhibition incubated for 7 days by WST-8 assay
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[PMID: 37849536] |
| MV4-11 | IC50 |
0.6 nM
Compound: 46; LSD1-UM-109
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Antiproliferative activity against human MV4-11 cells assessed as cell growth inhibition incubated for 10 days by WST-8 assay
Antiproliferative activity against human MV4-11 cells assessed as cell growth inhibition incubated for 10 days by WST-8 assay
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[PMID: 37849536] |
| NCI-H1417 | IC50 |
1.1 nM
Compound: 46; LSD1-UM-109
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Antiproliferative activity against human NCI-H1417 cells assessed as cell growth inhibition incubated for 10 days by WST-8 assay
Antiproliferative activity against human NCI-H1417 cells assessed as cell growth inhibition incubated for 10 days by WST-8 assay
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[PMID: 37849536] |
Chemical Information
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CAS. Nr. 2252446-26-5
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Molecular Weight 478.56
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Formel C29H27FN6
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SMILES
CN(N=C1)C2=C1C=C(C=C2)C3=C(C4=CC=C(C#N)C(F)=C4)C5=C(N(CC6(C)CCNCC6)C=C5)C=N3
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
LSD1-UM-109 Related Classifications
HY-149595 Related Classifications
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