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Art. -Nr.: HY-N10443

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Mammea A/BA

Mammea A/BA has potent activity against Trypanosoma cruzi (T. cruzi). Mammea A/BA induces mitochondrial dysfunction, reactive oxygen species (ROS) production and DNA fragmentation, and increases number of acidic vacuoles. Mammea A/BA can induce apoptosis, autophagy and necrosis. Mammea A/BA can be used for researching chagas disease.

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CAS. Nr.: 5224-54-4
Formel: C₂₅H₂₆O₅
Molecular Weight:406.47

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (272 KB)

Mammea A/BA Chemical Structure

CAS. Nr.: 5224-54-4

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- Cellular Effect
Chemical Information
Reinheit & Dokumentation
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Classifications
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Biologische Aktivität

Beschreibung

IC₅₀ & Target

T. cruzi^[1]

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Cellular Effect

Cell Line	Type	Value	Description	References
MCF7	GI₅₀	0.7 μg/mL Compound: 5	Cytotoxicity against human MCF7 cells Cytotoxicity against human MCF7 cells	[PMID: 15787438]
NCI-H460	GI₅₀	0.8 μg/mL Compound: 5	Cytotoxicity against human H460 cells Cytotoxicity against human H460 cells	[PMID: 15787438]
PC-3	IC₅₀	2.18 μM Compound: 13	Antiproliferative activity against human PC3 cells after 48 hrs Antiproliferative activity against human PC3 cells after 48 hrs	[PMID: 21214226]
SF-268	GI₅₀	0.6 μg/mL Compound: 5	Cytotoxicity against human SF268 cells Cytotoxicity against human SF268 cells	[PMID: 15787438]
T47D	IC₅₀	1.57 μM Compound: 13	Antiproliferative activity against human T47D cells after 48 hrs Antiproliferative activity against human T47D cells after 48 hrs	[PMID: 21214226]
T47D	IC₅₀	3.23 μM Compound: 13	Inhibition of hypoxia-induced HIF1 activation in human T47D cells expressing pGL3 construct after 16 hrs by cell-based luciferase reporter assay Inhibition of hypoxia-induced HIF1 activation in human T47D cells expressing pGL3 construct after 16 hrs by cell-based luciferase reporter assay	[PMID: 21214226]
T47D	IC₅₀	3.73 μM Compound: 13	Inhibition of 1,10-phenanthrolin-induced HIF1 activation in human T47D cells expressing pGL3 construct after 16 hrs by cell-based luciferase reporter assay Inhibition of 1,10-phenanthrolin-induced HIF1 activation in human T47D cells expressing pGL3 construct after 16 hrs by cell-based luciferase reporter assay	[PMID: 21214226]

Chemical Information

CAS. Nr. 5224-54-4
Molecular Weight 406.47
Formel C₂₅H₂₆O₅
SMILES

O=C1C=C(C2=CC=CC=C2)C3=C(O)C(C/C=C(C)\C)=C(O)C(C(CC(C)C)=O)=C3O1
Structure Classification
- Phenylpropanoids
- Coumarins
Initial Source
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (272 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Rodríguez-Hernández KD, et al. Mammea type coumarins isolated from Calophyllum brasiliense induced apoptotic cell death of Trypanosoma cruzi through mitochondrial dysfunction, ROS production and cell cycle alterations. Bioorg Chem. 2020 Jul;100:103894. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biologische Aktivität
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Mammea A/BA

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Biologische Aktivität

Beschreibung

IC50 & Target

Cellular Effect

Chemical Information

Reinheit & Dokumentation

Verweise

Calculators

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Mammea A/BA Related Classifications

HY-N10443 Related Classifications

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