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Art. -Nr.: HY-115888

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MIF2-IN-1

MIF2-IN-1 (compound 5d) is a potent inhibitor of MIF2 tautomerase with an IC₅₀ of 1.0 μM. MIF2-IN-1 suppresses the proliferation of non-small cell lung cancer cells by the induction of cell cycle arrest via deactivation of the MAPK pathway. MIF2-IN-1 has the potential for the research of cancer diseases.

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CAS. Nr.: 2917525-79-0
Formel: C₂₆H₁₉F₃N₂O₂S
Molecular Weight:480.50

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (271 KB)

MIF2-IN-1 Chemical Structure

CAS. Nr.: 2917525-79-0

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- Cellular Effect
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target

IC50: 1.0 μM (MIF2)^[1]

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	3 μM Compound: 5d	Antiproliferative against human A549 cells assessed as inhibition of cell viability measured after 72 hrs by fluorescence based assay Antiproliferative against human A549 cells assessed as inhibition of cell viability measured after 72 hrs by fluorescence based assay	[PMID: 35041425]
HCC827	IC₅₀	5.2 μM Compound: 5d	Antiproliferative against human HCC827 cells assessed as inhibition of cell viability measured after 72 hrs by fluorescence based assay Antiproliferative against human HCC827 cells assessed as inhibition of cell viability measured after 72 hrs by fluorescence based assay	[PMID: 35041425]
NCI-H1299	IC₅₀	7.6 μM Compound: 5d	Antiproliferative against human NCI-H1299 cells assessed as inhibition of cell viability measured after 72 hrs by fluorescence based assay Antiproliferative against human NCI-H1299 cells assessed as inhibition of cell viability measured after 72 hrs by fluorescence based assay	[PMID: 35041425]
NCI-H1650	IC₅₀	5.3 μM Compound: 5d	Antiproliferative against human NCI-H1650 cells assessed as inhibition of cell viability measured after 72 hrs by fluorescence based assay Antiproliferative against human NCI-H1650 cells assessed as inhibition of cell viability measured after 72 hrs by fluorescence based assay	[PMID: 35041425]

Chemical Information

CAS. Nr. 2917525-79-0
Molecular Weight 480.50
Formel C₂₆H₁₉F₃N₂O₂S
SMILES

O=C(NC1=C(C2=O)C(C)=C(C3=CC(C(F)(F)F)=CC=C3)S1)N2[C@H](C)C4=C5C(C=CC=C5)=CC=C4
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (271 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Xiao Z, et al. Thieno[2,3-d]pyrimidine-2,4(1H,3H)-dione Derivative Inhibits d-Dopachrome Tautomerase Activity and Suppresses the Proliferation of Non-Small Cell Lung Cancer Cells. J Med Chem. 2022 Feb 10;65(3):2059-2077. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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