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Art. -Nr.: HY-12689C

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Mitapivat hydrochloride

(Synonyms: AG-348 hydrochloride)

3 Cited Publications

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Based on 3 publication(s) in Google Scholar

Mitapivat (AG-348) hydrochloride is an orally active and selective allosteric pyruvate kinase R (PK-R) activator. Mitapivat hydrochloride accelerates the reaction of PK-R catalyzing the conversion of phosphoenolpyruvate to pyruvate, thereby promoting the glycolytic pathway, increasing the production of adenosine triphosphate (ATP) in red blood cells, and reducing the level of 2,3-diphosphoglycerate (2,3-DPG). Mitapivat hydrochloride is promising for research of pyruvate kinase deficiency and other anemia-related diseases.

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CAS. Nr.: 2559738-69-9
Formel: C₂₄H₂₇ClN₄O₃S
Molecular Weight:487.01

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Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

Mitapivat hydrochloride Chemical Structure

CAS. Nr.: 2559738-69-9

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Beschreibung

Chemical Information

CAS. Nr. 2559738-69-9
Molecular Weight 487.01
Formel C₂₄H₂₇ClN₄O₃S
SMILES

O=S(C1=C2N=CC=CC2=CC=C1)(NC3=CC=C(C(N4CCN(CC5CC5)CC4)=O)C=C3)=O.[H]Cl
Synonyms

AG-348 hydrochloride
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (3)

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J Sep Sci

Development and validation of stability indicating assay method for mitapivat: Identification of novel hydrolytic, photolytic, and oxidative forced degradation products employing quadrupole-time of flight mass spectrometry. [Abstract]

2024 Jul;47(14):e2400173. PMID: 39054589
J Mass Spectrom

Identification of Mitapivat's In Vivo Metabolites in the Rat Model by Quadrupole-Time-of-Flight (Q-TOF) Mass Spectrometry. [Abstract]

2025 May;60(5):e5126. PMID: 40195624
Sep Sci Plus

2025 Jan 07.

Mitapivat hydrochloride purchased from MedChemExpress. Usage Cited in: Sep Sci Plus. 2025 Jan 07.

Mean plasma concentration–time profile and log-plasma concentration–time profile of Mitapivat after a single oral dose of 5 mg/kg to SD rats (each data point corresponds to mean ± S.D., n = 4).

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Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (269 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Yang H, et al. Phase 1 Single- and Multiple-Ascending-Dose Randomized Studies of the Safety, Pharmacokinetics, and Pharmacodynamics of AG-348, a First-in-Class Allosteric Activator of Pyruvate Kinase R, in Healthy Volunteers. Clin Pharmacol Drug Dev. 2019 Feb;8(2):246-259. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

Mitapivat hydrochloride

3 Cited Publications

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Publications (3)
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Mitapivat hydrochloride purchased from MedChemExpress. Usage Cited in: Sep Sci Plus. 2025 Jan 07.

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Mean plasma concentration–time profile and log-plasma concentration–time profile of Mitapivat after a single oral dose of 5 mg/kg to SD rats (each data point corresponds to mean ± S.D., n = 4).

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Mitapivat hydrochloride

Publications Citing Use of MedChemExpress (MCE) Mitapivat hydrochloride

Biologische Aktivität

Chemical Information

Publications (3)

Reinheit & Dokumentation

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Mitapivat hydrochloride Related Classifications

HY-12689C Related Classifications