Moreollic acid
Moreollic acid is a PTP1B inhibitor, with an IC50 of 4.44 μM and a Ki of 1.75 μM against human targets. Moreollic acid blocks cell cycle progression from the G1 to S phase and inhibits tumor cell proliferation. Moreollic acid can be used in research related to type 2 diabetes, obesity, colon cancer and other cancers.
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- CAS. Nr.: 173792-68-2
- Formel: C34H40O9
- Molecular Weight:592.68
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
Biologische Aktivität
Moreollic acid (Compound 2) (5 μM; 48 h) potently inhibits the viability of HCT116 human colon cancer cells with an inhibition rate of 83.86%, whereas it exhibits only weak or no inhibitory effect on the viability of A549, MDA-MB-231 and KYSE30 cancer cells[2].
Moreollic acid (48 h) inhibits the viability of human colon cancer cells HCT116, DLD1 and SW620, with IC50 values of 1.71 μM, 1.44 μM and 1.49 μM, respectively; in contrast, it shows a higher IC50 value of 3.16 μM against normal NCM460 colonic epithelial cells[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:A549, MDA-MB-231, KYSE30, HCT116
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Concentration:5 μM
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Incubation Time:48 h
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Result:Inhibited HCT116 cell viability by 83.86%.
Showed minimal inhibition of A549 cell viability by 18.38%.
Showed minimal inhibition of MDA-MB-231 cell viability by -4.9%.
Showed minimal inhibition of KYSE30 cell viability by 20.76%.
Chemical Information
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CAS. Nr. 173792-68-2
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Molecular Weight 592.68
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Formel C34H40O9
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SMILES
OC(/C(C)=C\C[C@@]12[C@@]34[C@@](C(C5=C(O)C(C=CC(C)(O6)C)=C6C(C/C=C(C)\C)=C5O4)=O)([H])[C@H]([C@@](C[C@@]3([H])C(C)(O2)C)([H])C1=O)OC)=O
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
[1]. Tan XF, et al. Competitive protein tyrosine phosphatase 1B (PTP1B) inhibitors, prenylated caged xanthones from Garcinia hanburyi and their inhibitory mechanism. Bioorg Med Chem. 2017 Apr 15;25(8):2498-2506. [Content Brief]
[2]. Cheng LZ, et al. Structural Optimization and Improving Antitumor Potential of Moreollic Acid from Gamboge. Molecules. 2022;27(2):482. Published 2022 Jan 13. [Content Brief]
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Moreollic acid Related Classifications
HY-182463 Related Classifications
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