NEP(1-40)
Based on 2 publication(s) in Google Scholar
NEP(1-40) is a Nogo-66 receptor (NgR) antagonist peptide, reversing the injury-induced shift in distribution of microglia morphologies by limiting myelin-based inhibition.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- Reinheit : 98.24%
- CAS. Nr.: 475221-20-6
- Formel: C206H324N56O65
- Molecular Weight:4625.11
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Speicherung:
Sealed storage, away from moisture.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biologische Aktivität
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Chemical Information
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Lösungsmittel & Löslichkeit
- Protokoll
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
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HY-P1240
MOG (35-55) mouse, ratCNS Myelin Component -
![[SER140]-PLP(139-151)](https://file.medchemexpress.com/product_pic/hy-p1038.gif)
HY-P1038
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HY-107661
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HY-107660
SIRT2-IN-8SIRT2 Inhibitor -
HY-P0305
PrP (106-126)Prion Peptide Fragment -
HY-107662
TCS PrP Inhibitor 13PrP C Inhibitor -
HY-107661R
Arundic Acid (Standard)Astrocyte-modulating Agent -
HY-107662R
TCS PrP Inhibitor 13 (Standard)Reference Standard -
HY-P1243
C3bot(154-182)C3 Peptide
Publications Citing Use of MedChemExpress (MCE) NEP(1-40)
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Biologische Aktivität
Beschreibung
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:74 male Sprague-Dawley rats (328-377 g)[1].
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Dosage:89 μg/kg (97.5% PBS and 2.5% DMSO).
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Administration:IP, 15 min and 19 h post-injury.
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Result:Reduced NgR function immediately post-injury.
Increased number of amoeboid microglia/macrophages at 2 days post-injury
Chemical Information
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CAS. Nr. 475221-20-6
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Appearance Solid
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Molecular Weight 4625.11
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Formel C206H324N56O65
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Color White to off-white
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Sequence
Ac-Arg-Ile-Tyr-Lys-Gly-Val-Ile-Gln-Ala-Ile-Gln-Lys-Ser-Asp-Glu-Gly-His-Pro-Phe-Arg-Ala-Tyr-Leu-Glu-Ser-Glu-Val-Ala-Ile-Ser-Glu-Glu-Leu-Val-Gln-Lys-Tyr-Ser-Asn-Ser-NH2
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Sequence Shortening
Ac-RIYKGVIQAIQKSDEGHPFRAYLESEVAISEELVQKYSNS-NH2
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Sealed storage, away from moisture
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (2)
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Journal Impact Factor
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Most Recent
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Brain Behav
Baishaoluoshi Decoction Mitigates Post-Stroke Spasticity by Targeting Synaptic Plasticity Through the Nogo-A/NgR Signaling Pathway. [Abstract]2026 Jan;16(1):e71170. PMID: 41474227 -
Oncol Lett
Nogo-A/NgR signaling regulates stemness in cancer stem-like cells derived from U87MG glioblastoma cells. [Abstract]2022 May 27;24(1):230. PMID: 35720478
Lösungsmittel & Löslichkeit
In Vitro:
H2O : 22.22 mg/mL (4.80 mM; ultrasonic and adjust pH to 2 with 1 M HCl)
DMSO : < 1 mg/mL (insoluble or slightly soluble)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Protokoll
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Phagocytosis Functional Assay
A phagocytosis functional assay measures the ability of phagocytic cells, such as neutrophils, macrophages, monocytes, or microglia/macrophages, to bind and internalize particulate targets including bacteria, yeast particles, beads, or myelin particles. Fluorescent flow-cytometry assays detect target uptake as fluorescence associated with gated phagocytes, while pH-sensitive dyes such as pHrodo increase signal in acidic phagosomal compartments and therefore preferentially report internalized particles rather than particles remaining outside the cell. Microscopy or high-content imaging can be used to confirm intracellular localization and, in some protocols, to follow uptake kinetics.
Reinheit & Dokumentation
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Data Sheet (286 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
Verweise
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 0.2162 mL | 1.0811 mL | 2.1621 mL | 5.4053 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
NEP(1-40) Related Classifications
HY-P1242 Related Classifications
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