PBD-monoamide
Based on 1 Customer Validation
PBD-monoamide, a modified PBD (pyrrolobenzodiazepine) dimer, is an ADC Cytotoxin. PBD-monoamide can be used for synthesis of DHES0815A (an HER2 ADC). PBD-monoamide has DNA-binding activity and reduces cell viability.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- Reinheit: 96.41%
- CAS. Nr.: 2093165-00-3
- Formel: C33H36N4O7
- Molecular Weight:600.66
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Speicherung:
4°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biologische Aktivität
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Chemical Information
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Lösungsmittel & Löslichkeit
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
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Biologische Aktivität
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS. Nr. 2093165-00-3
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Appearance Solid
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Molecular Weight 600.66
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Formel C33H36N4O7
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Color White to off-white
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SMILES
O=C(C1=CC(OC)=C(OCCCCCOC2=C(OC)C=C3C(N=C[C@@]([H])(N(C3=O)C4)CC4=C)=C2)C=C1NC5=O)N([C@]5(C6)[H])CC6=C
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
4°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
Lösungsmittel & Löslichkeit
DMSO : 125 mg/mL (208.10 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Reinheit & Dokumentation
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Data Sheet (271 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
Verweise
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.6648 mL | 8.3242 mL | 16.6484 mL | 41.6209 mL |
| 5 mM | 0.3330 mL | 1.6648 mL | 3.3297 mL | 8.3242 mL | |
| 10 mM | 0.1665 mL | 0.8324 mL | 1.6648 mL | 4.1621 mL | |
| 15 mM | 0.1110 mL | 0.5549 mL | 1.1099 mL | 2.7747 mL | |
| 20 mM | 0.0832 mL | 0.4162 mL | 0.8324 mL | 2.0810 mL | |
| 25 mM | 0.0666 mL | 0.3330 mL | 0.6659 mL | 1.6648 mL | |
| 30 mM | 0.0555 mL | 0.2775 mL | 0.5549 mL | 1.3874 mL | |
| 40 mM | 0.0416 mL | 0.2081 mL | 0.4162 mL | 1.0405 mL | |
| 50 mM | 0.0333 mL | 0.1665 mL | 0.3330 mL | 0.8324 mL | |
| 60 mM | 0.0277 mL | 0.1387 mL | 0.2775 mL | 0.6937 mL | |
| 80 mM | 0.0208 mL | 0.1041 mL | 0.2081 mL | 0.5203 mL | |
| 100 mM | 0.0166 mL | 0.0832 mL | 0.1665 mL | 0.4162 mL |
PBD-monoamide Related Classifications
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