PD130883
PD130883 is an antifolate DHFR inhibitor that directly inhibits thymidylate synthase at the 5,10-methylenetetrahydrofolate binding site, reducing the net conversion of tetrahydrofolate cofactor to dihydrofolate.
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- CAS. Nr.: 123685-36-9
- Formel: C18H15N5O3
- Molecular Weight:349.34
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
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Biologische Aktivität
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| L1210 | IC50 |
2.4 μM
Compound: 10h
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Tested for 50% inhibition of L1210 cell growth in vitro
Tested for 50% inhibition of L1210 cell growth in vitro
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[PMID: 2362285] |
Chemical Information
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CAS. Nr. 123685-36-9
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Molecular Weight 349.34
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Formel C18H15N5O3
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SMILES
O=C1NC(N)=NC2=C1C=C(C=C2)CN(CC#C)C3=CC=C(C=C3)[N+]([O-])=O
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
PD130883 Related Classifications
HY-118251 Related Classifications
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