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Art. -Nr.: HY-153512

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PHD-1-IN-3

PHD-1-IN-3 is an orally active PHD-1 inhibitor with an IC₅₀ of 0.09 μM. PHD-1-IN-3 acts via monodentate binding interaction with active site Fe²⁺ ion.

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CAS. Nr.: 2009345-20-2
Formel: C₁₄H₁₁N₅
Molecular Weight:249.28

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

PHD-1-IN-3 Chemical Structure

CAS. Nr.: 2009345-20-2

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- In Vitro
- Parmacokinetics
Chemical Information
Reinheit & Dokumentation
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Calculators
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Biologische Aktivität

Beschreibung

PHD-1-IN-3 is an orally active PHD-1 inhibitor with an IC₅₀ of 0.09 μM. PHD-1-IN-3 acts via monodentate binding interaction with active site Fe²⁺ ion^[1].

Alle HIF/HIF Prolyl-Hydroxylase Isoform-spezifische Produkte anzeigen :

In Vitro

PHD-1-IN-3 (compound 53) acts as an MDR1 substrate in MDR1-MDCK cell monolayers^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Parmacokinetics

Species	Dose	Route	CL	AUC_0-t	C_max	F
Mice^[1]	3 mg/kg	p.o.	/	40038 ng·h/mL	14.8 μM	39 %
Mice^[1]	0.5 mg/kg	i.v.	0.48 mL/min/kg	/	/	/

Chemical Information

CAS. Nr. 2009345-20-2
Molecular Weight 249.28
Formel C₁₄H₁₁N₅
SMILES

N#CC=1C=CC(C2=CC(N)=CC3=NC=NN32)=C(C1)C
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. Ahmed S, et al. 1,2,4-Triazolo-[1,5-a]pyridine HIF Prolylhydroxylase Domain-1 (PHD-1) Inhibitors With a Novel Monodentate Binding Interaction. J Med Chem. 2017;60(13):5663-5672. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biologische Aktivität
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- In Vitro
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PHD-1-IN-3

Alle HIF/HIF Prolyl-Hydroxylase Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Reinheit & Dokumentation

Verweise

Calculators

Help & FAQs

PHD-1-IN-3 Related Classifications

HY-153512 Related Classifications