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Art. -Nr.: HY-178248

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PSMA-R2

PSMA ligand 2 is a prostate specific membrane antigen (PSMA) ligand with a glutamate-urea-lysine (GUL) moiety. PSMA ligand 2 can be efficiently labeled with radioactive nuclides such as ⁶⁸Ga and ¹⁷⁷Lu and specifically binds to PSMA-positive tumor cells. PSMA ligand 2 can be used for imaging of PSMA-expressing tumors or cells via PET or SPECT imaging. PSMA ligand 2 can be used for the research of prostate cancer.

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CAS. Nr.: 2576410-20-1
Formel: C₄₁H₆₃BrN₈O₁₅
Molecular Weight:987.89

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

PSMA-R2 Chemical Structure

CAS. Nr.: 2576410-20-1

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Use of MCE Products

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- In Vitro
- In Vivo
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

In Vitro

PSMA ligand 2 (Compound PSMA‑R2) (10 μg/mL; 30-120 min) exhibits good stability in human plasma, with 85% recovery remaining after 2 hours of incubation at 37°C and 10 μg/mL^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

PSMA ligand 2 (⁶⁸Ga‑PSMA‑R2) (4.44-5.55 MBq; i.v.; single dose) exhibits renal excretion in healthy CD-1 mice, with high initial bladder uptake and decreasing kidney and systemic organ uptake over 4 hours post-injection^[1].
PSMA ligand 2 (68Ga‑PSMA‑R2) (4.5 MBq; i.v.; single dose) exhibits high uptake in PSMA-positive prostate tumors in athymic nude mice at 1 hour post-injection, with a tumor-to-kidney ratio of 5^[1].
PSMA ligand 2 (111 MBq; i.v.; single dose) significantly reduces PSMA-positive prostate tumor volumes in athymic nude mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Mice bearing PC3-PIP^[1]
Dosage:

111 MBq
Administration:

i.v.; single dose
Result:

Reduced tumor volume.

Chemical Information

CAS. Nr. 2576410-20-1
Molecular Weight 987.89
Formel C₄₁H₆₃BrN₈O₁₅
SMILES

OC(CC[C@@H](C(O)=O)NC(N[C@H](C(O)=O)CCCCN(C(CCCCCNC(CN1CCN(CCN(CCN(CC1)CC(O)=O)CC(O)=O)CC(O)=O)=O)=O)CC2=CC=C(C=C2)Br)=O)=O
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. Maurizio F. MARIANI, et al. Prostate specific membrane antigen (psma) ligands and uses thereof. WO2021001360A1. 2022-01-02

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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