Pyrimidinone 8
Based on 1 Customer Validation
Pyrimidinone 8 is a reversible linear non-competitive inhibitor of divalent metal transporter 1 (DMT1), with a Ki of 20 μM (hDMT1). Pyrimidinone 8 does not affect hDMT1 cell surface expression and shows no dependence with the extracellular pH. Pyrimidinone 8 can inhibit hDMT1-mediated iron uptake, with an IC50 of 13.8 μM.
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- CAS. Nr.: 65004-42-4
- Formel: C10H12N4O
- Molecular Weight:204.23
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Speicherung:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biologische Aktivität
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Chemical Information
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Lösungsmittel & Löslichkeit
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
Biologische Aktivität
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HepG2 | CC50 |
60.7 μM
Compound: MMV393995
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HepG2 CC50 (uM) Cytotoxicity
HepG2 CC50 (uM) Cytotoxicity
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10.6019/CHEMBL3832761 |
| Vero | IC50 |
325 μM
Compound: 11
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Cytotoxicity against African green monkey Vero cells assessed as reduction in cell viability by MTT assay
Cytotoxicity against African green monkey Vero cells assessed as reduction in cell viability by MTT assay
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[PMID: 33395287] |
Chemical Information
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CAS. Nr. 65004-42-4
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Appearance Solid
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Molecular Weight 204.23
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Formel C10H12N4O
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Color White to off-white
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SMILES
O=C1N=C(N2N=C(C)C=C2C)NC(C)=C1
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Lösungsmittel & Löslichkeit
DMSO : 100 mg/mL (489.64 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Reinheit & Dokumentation
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Data Sheet (272 KB)
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SDS (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
Verweise
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 4.8964 mL | 24.4822 mL | 48.9644 mL | 122.4110 mL |
| 5 mM | 0.9793 mL | 4.8964 mL | 9.7929 mL | 24.4822 mL | |
| 10 mM | 0.4896 mL | 2.4482 mL | 4.8964 mL | 12.2411 mL | |
| 15 mM | 0.3264 mL | 1.6321 mL | 3.2643 mL | 8.1607 mL | |
| 20 mM | 0.2448 mL | 1.2241 mL | 2.4482 mL | 6.1206 mL | |
| 25 mM | 0.1959 mL | 0.9793 mL | 1.9586 mL | 4.8964 mL | |
| 30 mM | 0.1632 mL | 0.8161 mL | 1.6321 mL | 4.0804 mL | |
| 40 mM | 0.1224 mL | 0.6121 mL | 1.2241 mL | 3.0603 mL | |
| 50 mM | 0.0979 mL | 0.4896 mL | 0.9793 mL | 2.4482 mL | |
| 60 mM | 0.0816 mL | 0.4080 mL | 0.8161 mL | 2.0402 mL | |
| 80 mM | 0.0612 mL | 0.3060 mL | 0.6121 mL | 1.5301 mL | |
| 100 mM | 0.0490 mL | 0.2448 mL | 0.4896 mL | 1.2241 mL |
Pyrimidinone 8 Related Classifications
HY-124703 Related Classifications
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