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Art. -Nr.: HY-15584C

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(R)-Taltobulin

(Synonyms: (R)-HTI-286; (R)-SPA-110)

(R)-Taltobulin ((R)-HTI-286) can be used as a reference substance.

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CAS. Nr.: 228266-44-2
Formel: C₂₇H₄₃N₃O₄
Molecular Weight:473.65

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (264 KB)

(R)-Taltobulin Chemical Structure

CAS. Nr.: 228266-44-2

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Biologische Aktivität
- Beschreibung
- Cellular Effect
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

(R)-Taltobulin ((R)-HTI-286) can be used as a reference substance^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
HCT-15	IC₅₀	58 nM Compound: 41 (RSS isomer)	Inhibitory concentration against HCT-15 cells was evaluated Inhibitory concentration against HCT-15 cells was evaluated	[PMID: 15341492]
KB	IC₅₀	39 nM Compound: 41 (RSS isomer)	Concentration required to inhibit tumor cell growth in KB-8-5 cells Concentration required to inhibit tumor cell growth in KB-8-5 cells	[PMID: 15341492]
KB	IC₅₀	879 nM Compound: 41 (RSS isomer)	Concentration required to inhibit tumor cell growth in KB-V1 cells Concentration required to inhibit tumor cell growth in KB-V1 cells	[PMID: 15341492]
KB 3-1	IC₅₀	28 nM Compound: 41 (RSS isomer)	Concentration required to inhibit tumor cell growth in KB-3-1 cells Concentration required to inhibit tumor cell growth in KB-3-1 cells	[PMID: 15341492]
LOX IMVI	IC₅₀	37 nM Compound: 41 (RSS isomer)	Inhibitory concentration against Lox melanoma cells Inhibitory concentration against Lox melanoma cells	[PMID: 15341492]
MCF7	IC₅₀	10 nM Compound: 53, SPA123, Epi phenylhemiasterlin	Antimitotic activity against human MCF7 cells expressing p53 mutant by MTT assay Antimitotic activity against human MCF7 cells expressing p53 mutant by MTT assay	[PMID: 12608848]
MCF7	IC₅₀	25 nM Compound: 53, SPA123, Epi phenylhemiasterlin	Cytotoxicity activity against human MCF7 cells expressing p53 mutant by MTT assay Cytotoxicity activity against human MCF7 cells expressing p53 mutant by MTT assay	[PMID: 12608848]
NCI-H1299	IC₅₀	79 nM Compound: 41 (RSS isomer)	Inhibitory concentration against NCI-H1299 cells was evaluated Inhibitory concentration against NCI-H1299 cells was evaluated	[PMID: 15341492]

Chemical Information

CAS. Nr. 228266-44-2
Molecular Weight 473.65
Formel C₂₇H₄₃N₃O₄
SMILES

CC(C)(C1=CC=CC=C1)[C@@H](NC)C(N[C@@H](C(C)(C)C)C(N(C)[C@@H](C(C)C)/C=C(C)/C(O)=O)=O)=O
Synonyms

(R)-HTI-286; (R)-SPA-110
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (264 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Nieman JA, et al. Synthesis and antimitotic/cytotoxic activity of hemiasterlin analogues. J Nat Prod. 2003 Feb;66(2):183-99. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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