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Art. -Nr.: HY-126072

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(Rac)-GK563

(Rac)-GK563 is the isomer of GK563 (HY-138990). GK563 is a Ca²⁺-independent group VI phospholipase A2 (GVIA iPLA2) inhibitor.

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CAS. Nr.: 1983928-04-6
Formel: C₁₆H₂₂O₂
Molecular Weight:246.35

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

(Rac)-GK563 Chemical Structure

CAS. Nr.: 1983928-04-6

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität

Beschreibung

(Rac)-GK563 is the isomer of GK563 (HY-138990). GK563 is a Ca²⁺-independent group VI phospholipase A2 (GVIA iPLA2) inhibitor^[1].

Chemical Information

CAS. Nr. 1983928-04-6
Molecular Weight 246.35
Formel C₁₆H₂₂O₂
SMILES

O=C1OC(CCC)C1CCCCC=2C=CC=CC2
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Protokoll

All Cell Biology

Ca²⁺ Staining Technique
Ca²⁺ staining is an experimental technique that utilizes specific fluorescent probes (such as Fluo-4 AM, Fura-2, etc.) to qualitatively or quantitatively detect dynamic changes in intracellular Ca²⁺ concentrations; this is achieved by monitoring the changes in fluorescent signals generated when these probes bind to free intracellular calcium ions. The underlying principle relies primarily on the presence of chelating groups within the probe's molecular structure that possess high affinity for calcium ions.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. Dedaki C, et al. β-Lactones: A Novel Class of Ca²⁺-Independent Phospholipase A₂ (Group VIA iPLA₂) Inhibitors with the Ability To Inhibit β-Cell Apoptosis. J Med Chem. 2019;62(6):2916-2927. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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