Saquayamycin B1
Saquayamycin B1 has antimicrobial effect, but it has weaker effect against Gram-negative bacteria. Saquayamycin B1 has inhibitory effect on leukemia P388 cells and Adriamycin-resistant P388 cells.
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- CAS. Nr.: 99260-68-1
- Formel: C31H32O12
- Molecular Weight:596.58
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
Beschreibung
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| NCI-H460 | GI50 |
13.2 μM
Compound: 6
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Growth inhibition of human NCI-H460 cells incubated for 48 hrs by resazurin dye reduction based fluorimetric assay
Growth inhibition of human NCI-H460 cells incubated for 48 hrs by resazurin dye reduction based fluorimetric assay
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[PMID: 22758660] |
| PC-3 | GI50 |
1.759 μM
Compound: 6
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Growth inhibition of human PC3 cells incubated for 48 hrs by resazurin dye reduction based fluorimetric assay
Growth inhibition of human PC3 cells incubated for 48 hrs by resazurin dye reduction based fluorimetric assay
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[PMID: 22758660] |
Chemical Information
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CAS. Nr. 99260-68-1
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Molecular Weight 596.58
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Formel C31H32O12
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SMILES
O=C1C[C@](C)(O)C[C@]2(O)[C@@]1(O)C(C(C3=CC=C([C@H]4C[C@@]5([H])O[C@](CC([C@H](C)O6)=O)([H])[C@]6([H])O[C@]5([H])[C@@H](C)O4)C(O)=C3C7=O)=O)=C7C=C2
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Structure Classification
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Initial Source
Streptomyces sp. XZHG99T
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Protokoll
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Research Protocol for Infectious Diseases
Infectious-disease experiments test how pathogens interact with host barriers, innate immune receptors, inflammatory signaling, pathogen replication, and tissue injury; pattern-recognition receptors such as TLRs, RIG-I-like receptors, NOD-like receptors, and inflammasomes detect microbial molecules and activate NF-κB, interferon, and cytokine responses. The central hypothesis is that infection severity reflects the balance between pathogen burden and host response: protective inflammation restricts pathogen growth, whereas excessive or mislocalized inflammation contributes to tissue damage and disease phenotype. Unresolved questions include which host pathways are protective versus pathogenic, why some infection models fail to translate to human disease, and which combined readouts best predict clinically relevant infection outcomes.
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Gram Staining of Tissue Sections
Gram staining of tissue sections is a histochemical technique used to differentiate Gram-positive and Gram-negative bacteria within histological specimens based on differences in bacterial cell wall structure and dye retention, adapted from classical bacteriological Gram staining into tissue-compatible “histological Gram stain” variants. In tissue applications, modifications of the Brown-Hopps and Brown-Brenn methods are commonly used to improve differentiation of microorganisms embedded within host connective tissue and to reduce overstaining or loss of Gram-negative signal, which are known limitations of earlier approaches. The principle relies on crystal violet-iodine complex retention in Gram-positive organisms and subsequent decolorization and counterstaining steps that allow contrast visualization of Gram-negative organisms against tissue background.
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Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Saquayamycin B1 Related Classifications
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