Scientific Reviews
Product Guides
Blogs
Topics
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
11 Results for "
actin depolymerization
" in MedChemExpress (MCE) Product Catalog:
Products (11)
11 Results for "actin depolymerization" in MCE Product Catalog:
100
Target:
2
2 Cited Publications
Art. -Nr.: HY-N2438
CAS. Nr.: 74805-91-7
Category:
Ophiopogon japonicus (L. f.) Ker-Gawl. Liliaceae Flavonoids Other Diseases Phenols Polyphenols Plants Disease Research Fields Other Flavonoids
Target:
Art. -Nr.: HY-W002112
CAS. Nr.: 5746-86-1
Synonyms: Nornicotine
Art. -Nr.: HY-P2031
CAS. Nr.: 26645-35-2
Target:
Art. -Nr.: HY-N6772
CAS. Nr.: 36011-19-5
Target:
Art. -Nr.: HY-W002112S
CAS. Nr.: 66148-18-3
Synonyms: Nornicotine-d4
Art. -Nr.: HY-151189
CAS. Nr.: 2488395-07-7
ROCK-IN-4 is a potent ROCK inhibitor maintaining NO releasing ability. ROCK-IN-4 reversibly depolymerizes F-actin, and suppresses mitochondrial respiration in human trabecular meshwork (HTM) cells. ROCK-IN-4 can be used for glaucoma or ocular hypertension research .
Art. -Nr.: HY-W002112R
CAS. Nr.: 5746-86-1
Synonyms: Nornicotine (Standard)
Art. -Nr.: HY-W002112S1
Synonyms: Nornicotine-d7
Art. -Nr.: HY-182478
CAS. Nr.: 124711-23-5
Target:
Forschungsgebiete:
MDL-27048, a tubulin inhibitor, binds competitively, reversibly to the Colchicine (HY-16569)-binding site on tubulin heterodimers. MDL-27048 inhibits microtubule assembly, induces slow depolymerization of preassembled microtubules, disrupts microtubule polymerization-depolymerization dynamics, and disrupts cytoplasmic microtubule networks. MDL-27048 exerts growth inhibitory effects on human cancer cells, induces mitotic arrest, and does not disrupt actin filaments at microtubule-depolymerizing concentrations. MDL-27048 can be used for the research of malignant tumors .
Art. -Nr.: HY-183147A
Target:
Forschungsgebiete:
LAT1-IN-2 hydrochloride is an orally active anticancer agent, as well as a LAT1 substrate and tubulin-binding agent. LAT1-IN-2 hydrochloride relies on LAT1 for cellular uptake, disrupts microtubule formation by binding to the colchicine site of tubulin, and induces actin depolymerization to transform cells into a spherical shape. LAT1-IN-2 hydrochloride effectively inhibits tumor growth in xenograft mice. Compared with Etoposide (HY-13629), LAT1-IN-2 hydrochloride shows higher distribution in tumor tissues, lower distribution in major organs, and better tolerability. LAT1-IN-2 hydrochloride has been applied in studies related to esophageal cancer .
- 1
-
-
Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
