Selank diacetate
Based on 1 Customer Validation
Selank diacetate (Selanc diacetate; TP-7 diacetate) is a GABAA receptor modulator with anxiolytic activity. Selank diacetate allosterically modulates the specific binding of GABA to GABAA receptors and alters the affinity of endogenous ligands for these receptors. Selank diacetate reduces elevated anxiety levels, attenuates stress-induced exacerbation of anxiety, and produces a synergistic anxiolytic effect with diazepam. Selank diacetate can be used in the research of anxiety disorders.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- Reinheit : 99.37%
- Formel: C37H65N11O13
- Molecular Weight:871.98
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Speicherung:
Sealed storage, away from moisture and light.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biologische Aktivität
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Chemical Information
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Lösungsmittel & Löslichkeit
- Protokoll
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
Biologische Aktivität
Beschreibung
In Vivo
Selank (300 μg/kg; i.n.; once daily; 14 days) diacetate significantly mitigates stress-induced anxiety-related behavioral deterioration in UCMS-exposed rats compared to saline-treated controls[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Wistar rats (male, average weight 400 g)[1]
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Dosage:300 μg/kg
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Administration:i.n.; once daily; 14 days
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Result:Decreased median time spent in open arms from 40.2 s to 12.2 s.
Increased median time spent in closed arms from 124.9 s to 147.7 s.
Decreased median number of hanging events from open arms from 7 to 5.
Decreased median number of squares crossed minimally from 36 to 30.
Maintained median number of rears at 9.5.
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Animal Model:Wistar rats (male, average weight 400 g, UCMS-induced anxiety)[1]
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Dosage:300 μg/kg
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Administration:i.n.; once daily; 14 days (concurrent with UCMS exposure)
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Result:Decreased median time spent in open arms from 64.7 s (41.7-79.4 s IQR) to 15.5 s (7-26.6 s IQR).
Increased median time spent in closed arms from 104.7 s to 139.9 s.
Decreased median number of hanging events from open arms from 9 to 4.5.
Decreased median number of squares crossed from 39 to 22.
Decreased median number of rears from 6.5 to 5.5.
Exhibited magnitude of anxiety indicator changes similar to non-stressed rats administered Selank, and significantly less severe than changes observed in UCMS-exposed rats administered saline.
Chemical Information
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Appearance Solid
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Molecular Weight 871.98
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Formel C37H65N11O13
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Color White to off-white
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Synonyms
Selanc diacetate; TP-7 diacetate
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Sequence
Thr-Lys-Pro-Arg-Pro-Gly-Pro
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Sequence Shortening
TKPRPGP
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Sealed storage, away from moisture and light
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Lösungsmittel & Löslichkeit
In Vitro:
H2O : 250 mg/mL (286.70 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Reinheit & Dokumentation
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Data Sheet (276 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
Verweise
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| H2O | 1 mM | 1.1468 mL | 5.7341 mL | 11.4682 mL | 28.6704 mL |
| 5 mM | 0.2294 mL | 1.1468 mL | 2.2936 mL | 5.7341 mL | |
| 10 mM | 0.1147 mL | 0.5734 mL | 1.1468 mL | 2.8670 mL | |
| 15 mM | 0.0765 mL | 0.3823 mL | 0.7645 mL | 1.9114 mL | |
| 20 mM | 0.0573 mL | 0.2867 mL | 0.5734 mL | 1.4335 mL | |
| 25 mM | 0.0459 mL | 0.2294 mL | 0.4587 mL | 1.1468 mL | |
| 30 mM | 0.0382 mL | 0.1911 mL | 0.3823 mL | 0.9557 mL | |
| 40 mM | 0.0287 mL | 0.1434 mL | 0.2867 mL | 0.7168 mL | |
| 50 mM | 0.0229 mL | 0.1147 mL | 0.2294 mL | 0.5734 mL | |
| 60 mM | 0.0191 mL | 0.0956 mL | 0.1911 mL | 0.4778 mL | |
| 80 mM | 0.0143 mL | 0.0717 mL | 0.1434 mL | 0.3584 mL | |
| 100 mM | 0.0115 mL | 0.0573 mL | 0.1147 mL | 0.2867 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Selank diacetate Related Classifications
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