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Art. -Nr.: HY-105270A

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Tallimustine hydrochloride

(Synonyms: FCE 24517 hydrochloride)

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Tallimustine hydrochloride, a distamycin-A derivative, is an anticancer agent.

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Reinheit: 98.23%
CAS. Nr.: 118438-45-2
Formel: C₃₂H₃₉Cl₃N₁₀O₄
Molecular Weight:734.08

Speicherung:

4°C, sealed storage, away from moisture

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Tallimustine hydrochloride Chemical Structure

CAS. Nr.: 118438-45-2

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- Cellular Effect
Chemical Information
Lösungsmittel & Löslichkeit
- In Vitro
Reinheit & Dokumentation
Verweise
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

Tallimustine hydrochloride, a distamycin-A derivative, is an anticancer agent^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
L1210	IC₅₀	0.05 μg/mL Compound: 1 (Tallimustine)	In vitro inhibition of L1210 murine leukemia (Drug sensitivity was determined by counting surviving cells after 48 hr of continuous exposure to at least 4 conc. of drug) In vitro inhibition of L1210 murine leukemia (Drug sensitivity was determined by counting surviving cells after 48 hr of continuous exposure to at least 4 conc. of drug)	10.1016/0960-894X(96)00205-3
L1210	IC₅₀	0.42 nM Compound: tallimustine	Inhibition of growth in L1210 leukemia cells resistant to doxorubicin(DX). Inhibition of growth in L1210 leukemia cells resistant to doxorubicin(DX).	[PMID: 10893305]
L1210	IC₅₀	1.2 nM Compound: tallimustine	Inhibition of growth in L1210 leukemia cells resistant to Tallimustine. Inhibition of growth in L1210 leukemia cells resistant to Tallimustine.	[PMID: 10893305]
L1210	IC₅₀	24.4 ng/mL Compound: 7a (FCE 24517, Tallimustine)	The activity in vitro on L1210 murine leukemia cells, activity expressed as IC50 The activity in vitro on L1210 murine leukemia cells, activity expressed as IC50	10.1016/S0960-894X(01)80515-1
L1210	IC₅₀	50.3 ng/mL Compound: 1a	In vitro test for cytotoxicity after 48 hr of continuous exposure against L1210 murine leukemia cells In vitro test for cytotoxicity after 48 hr of continuous exposure against L1210 murine leukemia cells	10.1016/S0960-894X(97)10120-2
L1210	IC₅₀	50.3 ng/mL Compound: 4 (Tallimustine)	In vitro inhibition of L1210 murine leukemia (Drug sensitivity was determined by counting surviving cells after 48 hr of continuous exposure to at least 4 conc. of drug) In vitro inhibition of L1210 murine leukemia (Drug sensitivity was determined by counting surviving cells after 48 hr of continuous exposure to at least 4 conc. of drug)	10.1016/0960-894X(96)00204-1
L1210	IC₅₀	68.5 nM Compound: 1 (Tallimustine)	In vitro cytotoxicity against L1210 murine leukemia cells In vitro cytotoxicity against L1210 murine leukemia cells	[PMID: 10937717]
L1210	IC₅₀	68.5 nM Compound: tallimustine	In vitro antitumor activity evaluated against L1210 murine leukemia cell line In vitro antitumor activity evaluated against L1210 murine leukemia cell line	[PMID: 10893305]

Chemical Information

CAS. Nr. 118438-45-2
Appearance Solid
Molecular Weight 734.08
Formel C₃₂H₃₉Cl₃N₁₀O₄
Color Light yellow to light brown
SMILES

O=C(C1=CC=C(N(CCCl)CCCl)C=C1)NC2=CN(C)C(C(NC3=CN(C)C(C(NC4=CN(C)C(C(NCCC(N)=N)=O)=C4)=O)=C3)=O)=C2.Cl
Synonyms

FCE 24517 hydrochloride
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

4°C, sealed storage, away from moisture

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Lösungsmittel & Löslichkeit

In Vitro:

DMSO : 83.33 mg/mL (113.52 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

1.3622 mL

6.8112 mL

13.6225 mL

5 mM

0.2724 mL

1.3622 mL

2.7245 mL

10 mM

0.1362 mL

0.6811 mL

1.3622 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (267 KB)
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Herzig MC, et al. Tallimustine lesions in cellular DNA are AT sequence-specific but not region-specific. Biochemistry. 1999 Oct 19;38(42):14045-55. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	1.3622 mL	6.8112 mL	13.6225 mL	34.0562 mL
	5 mM	0.2724 mL	1.3622 mL	2.7245 mL	6.8112 mL
	10 mM	0.1362 mL	0.6811 mL	1.3622 mL	3.4056 mL
	15 mM	0.0908 mL	0.4541 mL	0.9082 mL	2.2704 mL
	20 mM	0.0681 mL	0.3406 mL	0.6811 mL	1.7028 mL
	25 mM	0.0545 mL	0.2724 mL	0.5449 mL	1.3622 mL
	30 mM	0.0454 mL	0.2270 mL	0.4541 mL	1.1352 mL
	40 mM	0.0341 mL	0.1703 mL	0.3406 mL	0.8514 mL
	50 mM	0.0272 mL	0.1362 mL	0.2724 mL	0.6811 mL
	60 mM	0.0227 mL	0.1135 mL	0.2270 mL	0.5676 mL
	80 mM	0.0170 mL	0.0851 mL	0.1703 mL	0.4257 mL
	100 mM	0.0136 mL	0.0681 mL	0.1362 mL	0.3406 mL

Keywords

MOQ

Minimum order quantity

100 mg

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Biologische Aktivität
- Beschreibung
Chemical Information
Lösungsmittel & Löslichkeit
- In Vitro
Reinheit & Dokumentation
Verweise

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Tallimustine hydrochloride

MCE Bioactive Compound Library

Biologische Aktivität

Chemical Information

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

Tallimustine hydrochloride Related Classifications

HY-105270A Related Classifications