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Art. -Nr.: HY-160421

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TREM2-IN-1

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TREM2-IN-1 (OPA) is a TREM2 inhibitor derived from oxaliplatin and artesunate. TREM2-IN-1 can relieves immunosuppressive tumor microenvironment and enhancing chemical anticancer efficiency. TREM2-IN-1 deters the tumor growth in mice models bearing MC38 colorectal tumor by reducing the number of CD206⁺ and CX₃CR1⁺ immunosuppressive macrophages. TREM2-IN-1 also promotes the expansion and infiltration of immunostimulatory dendritic, cytotoxic T and natural killer cells.

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Reinheit: 99.34%
CAS. Nr.: 2000236-36-0
Formel: C₄₆H₆₈N₂O₂₀Pt
Molecular Weight:1164.12

Speicherung:

-20°C, sealed storage, away from moisture and light

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

TREM2-IN-1 Chemical Structure

CAS. Nr.: 2000236-36-0

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target

TREM2^[1]

In Vitro

TREM2-IN-1 (0.8 μM, 72 h) inhibits the prophase of DNA synthesis (G1 phase) and has potent proapoptotic ability in HCT-116 cells^[1].
TREM2-IN-1 (1 μM, 24 h) remarkably inhibits the expression of TREM2 in the THP-1-derived macrophages^[1].

IC₅₀ (μM) of TREM2-IN-1 at 72 h against different cell lines^[1]

Complex	HCT-116	HepG2	PANC-1	U87-MG	HK-2
TREM2-IN-1	0.84	7.32	5.26	22.23	16.29

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cycle Analysis^[1]

Cell Line:

HCT-116 cells
Concentration:

0.8 μM
Incubation Time:

72 h
Result:

Increased the cells in the G1 phase from 24.81% to 48.96% in HCT-116 cells.

Apoptosis Analysis^[1]

Cell Line:

HCT-116 cells
Concentration:

0.8 μM
Incubation Time:

72 h
Result:

Induced 5.17% and 30.9% of HCT-116 cells to enter the early and late apoptosis respectively at 0.8 μM.

In Vivo

TREM2-IN-1 (1.5 mg Pt per kg, treat, a single dose for 15 days) effectively inhibits the growth of tumor with low general toxicity in C57BL/6 mice models bearing MC38 murine colorectal cancer^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

C57BL/6 mice models bearing MC38 murine colorectal cancer^[2]
Dosage:

1.5 mg Pt per kg
Administration:

treat, a single dose for 15 days
Result:

Effectively suppressed the tumor growth to the volume of 185.75 mm³ in C57BL/6 mice models bearing MC38 murine colorectal cancer.

Chemical Information

CAS. Nr. 2000236-36-0
Appearance Solid
Molecular Weight 1164.12
Formel C₄₆H₆₈N₂O₂₀Pt
Color White to off-white
SMILES

O=C(O[C@@H]1[C@H](C)[C@@](CC[C@@H](C)[C@]2([H])CC[C@](OO3)(C)O4)([H])[C@@]23[C@]4([H])O1)CCC(O[Pt]5(OC6=O)(OC6=O)(OC(CCC(O[C@@H]7[C@H](C)[C@@](CC[C@@H](C)[C@]8([H])CC[C@]9(C)O%10)([H])[C@@]8(OO9)[C@]%10([H])O7)=O)=O)[NH2][C@H](CCCC%11)[C@@H]%11[NH2]5)=O
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

-20°C, sealed storage, away from moisture and light

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (277 KB)
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Yang T, et al. Platinum-Based TREM2 Inhibitor Suppresses Tumors by Remodeling the Immunosuppressive Microenvironment. Angew Chem Int Ed Engl. 2023 Jan 9;62(2):e202213337. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

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