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Cat. No.: HY-164264

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Caged MK801

Caged MK801 is a photolabile NMDA receptor open-channel blocker. Caged MK801 releases MK801 upon photolysis activation, producing use-dependent blockade of NMDA receptor currents and synaptic NMDA receptor-mediated currents. Caged MK801 releases MK801 by photolysis in the postsynaptic region (somatodendritic region), which blocks the induction of timing-dependent long-term potentiation (t-LTP). Caged MK801 can be used in research related to neurological diseases.

For research use only. We do not sell to patients.

CAS No.: 217176-91-5
Formula: C₂₆H₂₄N₂O₆
Molecular Weight:460.48

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (276 KB)

Caged MK801 Chemical Structure

CAS No.: 217176-91-5

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
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Biological Activity

Description

IC₅₀ & Target

^[1]

NMDA Receptor

All iGluR Isoforms :

In Vitro

Glutamate Release or Receptors

Caged MK801 (1 mM; 1 s somatic dendritic UV flash) completely blocks the induction of time-dependent long-term potentiation (t-LTP) in L2/3 pyramidal cells, whereas the same pairing stimulation protocol induces robust t-LTP in the absence of UV flash^[1].
Caged MK801 (1 mM; axonal UV flash) blocks t-LTD induction in paired L4-L2/3 recordings, whereas soma-dendritic flash does not block t-LTD^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 217176-91-5
Molecular Weight 460.48
Formula C₂₆H₂₄N₂O₆
SMILES

COC(C=C1COC(N2[C@@H]3CC4=C([C@]2(C)C5=CC=CC=C53)C=CC=C4)=O)=C(C=C1[N+]([O-])=O)OC
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (276 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Rodríguez-Moreno A, et al. Presynaptic induction and expression of timing-dependent long-term depression demonstrated by compartment-specific photorelease of a use-dependent NMDA receptor antagonist. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2011 Jun 08;31(23):8564-8569. [Content Brief]

[2]. Reeve JE, et al. Caged intracellular NMDA receptor blockers for the study of subcellular ion channel function. Communicative & integrative biology. 2012 May 01;5(3):240-2.

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References

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Caged MK801

All iGluR Isoforms

Biological Activity

Description

IC50 & Target

In Vitro

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

Caged MK801 Related Classifications

HY-164264 Related Classifications

Bioz

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