Filastatin
Based on 1 Customer Validation
Filastatin is a long-lasting inhibitor of Candida albicans filamentation. Filastatin inhibits adhesion by multiple pathogenic Candida species with an IC50 of ~3 μM in the GFP-based adhesion assay. Filastatin inhibits fungal adhesion to polystyrene and human cells, the yeast-to-hyphal morphological transition, induction of the hyphal-specific HWP1 promoter. Filastatin has potent antifungal effect.
For research use only. We do not sell to patients.
- Purity: 99.27%
- CAS No.: 431996-53-1
- Formula: C18H18ClN3O3
- Molecular Weight:359.81
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Filastatin does not affect the viability of human A549 cells, even at concentrations much larger than those concentrations used in the adhesion assay (e.g., 250 μM)[1].
Filastatin can impair fungal adhesion to both inert surfaces and cultured human epithelial cells[1].
Filastatin inhibits polystyrene adhesion by C. dubliniensis and C. tropicalis and to a lesser extent, C. parapsilosis. Filastatin, therefore, inhibits adhesion by multiple pathogenic Candida species[1].
Filastatin inhibits C. albicans biofilm formation[1].
Filastatin inhibits hyphal morphogenesis and colony morphology[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 431996-53-1
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Appearance Solid
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Molecular Weight 359.81
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Formula C18H18ClN3O3
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Color Light yellow to yellow
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SMILES
O=C(C1=CC=C(C)C(Cl)=C1)N2CCN(C3=CC=C([N+]([O-])=O)C=C3)CC2
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 125 mg/mL (347.41 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (281 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| DMSO | 1 mM | 2.7792 mL | 13.8962 mL | 27.7924 mL | 69.4811 mL |
| 5 mM | 0.5558 mL | 2.7792 mL | 5.5585 mL | 13.8962 mL | |
| 10 mM | 0.2779 mL | 1.3896 mL | 2.7792 mL | 6.9481 mL | |
| 15 mM | 0.1853 mL | 0.9264 mL | 1.8528 mL | 4.6321 mL | |
| 20 mM | 0.1390 mL | 0.6948 mL | 1.3896 mL | 3.4741 mL | |
| 25 mM | 0.1112 mL | 0.5558 mL | 1.1117 mL | 2.7792 mL | |
| 30 mM | 0.0926 mL | 0.4632 mL | 0.9264 mL | 2.3160 mL | |
| 40 mM | 0.0695 mL | 0.3474 mL | 0.6948 mL | 1.7370 mL | |
| 50 mM | 0.0556 mL | 0.2779 mL | 0.5558 mL | 1.3896 mL | |
| 60 mM | 0.0463 mL | 0.2316 mL | 0.4632 mL | 1.1580 mL | |
| 80 mM | 0.0347 mL | 0.1737 mL | 0.3474 mL | 0.8685 mL | |
| 100 mM | 0.0278 mL | 0.1390 mL | 0.2779 mL | 0.6948 mL |
Filastatin Related Classifications
HY-124701 Related Classifications
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