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DXO - decapping exoribonuclease Gene

Also Known as NG6; RAI1; DOM3L; DOM3Z

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 1797

About DXO

Cytogenetic location: 6p21.33 Genomic coordinates (GRCh38): 6:31,969,815-31,972,138 (from NCBI)

This gene has 15 transcripts (splice variants), 1 gene allele and 202 orthologues. Ubiquitous expression in testis (RPKM 17.8), adrenal (RPKM 16.9) and 25 other tissues.

Summary

This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. The function of its protein product is unknown, but its ubiquitous expression and conservation in both simple and complex eukaryotes suggests that this may be a housekeeping gene. [provided by RefSeq, Jul 2008]

DXO Products (3)

mRNA	Protein	Name
NM_001371205.1	NP_001358134.1	decapping and exoribonuclease protein isoform 1
NM_001371206.1	NP_001358135.1	decapping and exoribonuclease protein isoform 1
NM_005510.4	NP_005501.2	decapping and exoribonuclease protein isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32814053	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in NAD-cap decapping	IDA IDA: Inferred from direct assay	28283058	GOA
involved in mRNA catabolic process	IDA IDA: Inferred from direct assay	29601584	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in nucleus	IDA IDA: Inferred from direct assay	29601584	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DXO Protein Structure

RAI1

0
100
200
300
396 a.a.

Protein Preferred Names	Protein Names
decapping and exoribonuclease protein	5'-3' exoribonuclease DXO

DXO Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	DXO	O77932	FKBP1A	Homo sapiens	Q0VDC6	Validated Y2H	32814053
Intra	DXO	O77932	FKBP1A	Homo sapiens	Q0VDC6	Y2H Array	32814053
Intra	DXO	O77932	FKBP1A	Homo sapiens	Q0VDC6	Y2H Pooling	32814053
Intra	DXO	O77932	SARS1	Homo sapiens	P49591	Y2H Array	32814053
Intra	DXO	O77932	SARS1	Homo sapiens	P49591	Y2H Pooling	32814053
Intra	DXO	O77932	SARS1	Homo sapiens	P49591	Validated Y2H	32814053
Intra	DXO	O77932	EIF2S3	Homo sapiens	P41091	Validated Y2H	32814053
Intra	DXO	O77932	EIF2S3	Homo sapiens	P41091	Y2H Array	32814053
Intra	DXO	O77932	EIF2S3	Homo sapiens	P41091	Y2H Pooling	32814053
Intra	DXO	O77932	KIF1B	Homo sapiens	O60333-2	Y2H Pooling	32814053
Intra	DXO	O77932	KIF1B	Homo sapiens	O60333-2	Validated Y2H	32814053
Intra	DXO	O77932	KIF1B	Homo sapiens	O60333-2	Y2H Array	32814053
Intra	DXO	O77932	BAG6	Homo sapiens	P46379-2	Validated Y2H	32814053
Intra	DXO	O77932	BAG6	Homo sapiens	P46379-2	Y2H Array	32814053
Intra	DXO	O77932	BAG6	Homo sapiens	P46379-2	Y2H Pooling	32814053
Intra	DXO	O77932	ERN1	Homo sapiens	O75460-2	Validated Y2H	32814053
Intra	DXO	O77932	ERN1	Homo sapiens	O75460-2	Y2H Pooling	32814053
Intra	DXO	O77932	ERN1	Homo sapiens	O75460-2	Y2H Array	32814053
Intra	DXO	O77932	HSPB1	Homo sapiens	P04792	Validated Y2H	32814053
Intra	DXO	O77932	HSPB1	Homo sapiens	P04792	Y2H Pooling	32814053
Intra	DXO	O77932	HSPB1	Homo sapiens	P04792	Y2H Array	32814053
Intra	DXO	O77932	VIM	Homo sapiens	P08670	Validated Y2H	32814053
Intra	DXO	O77932	VIM	Homo sapiens	P08670	Y2H Array	32814053
Intra	DXO	O77932	VIM	Homo sapiens	P08670	Y2H Pooling	32814053
Intra	DXO	O77932	CCT7	Homo sapiens	Q99832	Y2H Array	32814053
Intra	DXO	O77932	CCT7	Homo sapiens	Q99832	Y2H Pooling	32814053
Intra	DXO	O77932	CCT7	Homo sapiens	Q99832	Validated Y2H	32814053
Intra	DXO	O77932	RNF11	Homo sapiens	Q9Y3C5	Y2H Pooling	32814053
Intra	DXO	O77932	RNF11	Homo sapiens	Q9Y3C5	Validated Y2H	32814053
Intra	DXO	O77932	RNF11	Homo sapiens	Q9Y3C5	Y2H Array	32814053
Intra	DXO	O77932	PECAM1	Homo sapiens	P16284	Validated Y2H	32814053
Intra	DXO	O77932	PECAM1	Homo sapiens	P16284	Y2H Array	32814053
Intra	DXO	O77932	PECAM1	Homo sapiens	P16284	Y2H Pooling	32814053
Intra	DXO	O77932	WFS1	Homo sapiens	O76024	Y2H Array	32814053
Intra	DXO	O77932	WFS1	Homo sapiens	O76024	Y2H Pooling	32814053
Intra	DXO	O77932	WFS1	Homo sapiens	O76024	Validated Y2H	32814053
Intra	DXO	O77932	PRPS1	Homo sapiens	P60891	Validated Y2H	32814053
Intra	DXO	O77932	PRPS1	Homo sapiens	P60891	Y2H Array	32814053
Intra	DXO	O77932	PRPS1	Homo sapiens	P60891	Y2H Pooling	32814053

Cross: Cross-species interaction Intra: Intraspecies interaction

DXO Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P810030	DOM3Z Antibody (YA9374)	WB, ICC/IF, IF-Tissue, IHC-P, IP, ELISA	human, mouse, rat

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04079	DXO Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	DXO	RGD	RGD:1303267
Bos taurus	DXO	VGNC	VGNC:50147
Macaca mulatta	DXO	VGNC	VGNC:71970
Mus musculus	DXO	MGD	MGI:1890444
Felis catus	DXO	VGNC	VGNC:61673
Canis familiaris	DXO	VGNC	VGNC:40140
Others	DXO	NCBI