Pdcd4 - programmed cell death 4 Gene

Also Known as Ma3; Tis; D19Ucla1

Species: Mus musculus

Gene Type: protein coding
Gene ID: 18569

Summary

Predicted to enable RNA binding activity. Involved in cellular response to lipopolysaccharide; negative regulation of cytokine production involved in inflammatory response; and positive regulation of inflammatory response. Predicted to be located in cytoplasm. Predicted to be active in cytosol and nucleus. Is expressed in several structures, including brain; early conceptus; epithelium; oocyte; and thymus primordium. Orthologous to human PDCD4 (programmed cell death 4). [provided by Alliance of Genome Resources, Apr 2022]

Pdcd4 Products (3)

mRNA Protein Name
NM_001168491.1 NP_001161963.1 programmed cell death protein 4
NM_001168492.1 NP_001161964.1 programmed cell death protein 4
NM_011050.4 NP_035180.2 programmed cell death protein 4

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
12482958 MGI
Biological Process GO Annotation Evidence References Source
involved in cellular response to lipopolysaccharide IMP
IMP: Inferred from mutant phenotype
19946272 MGI
involved in negative regulation of cytokine production involved in inflammatory response IMP
IMP: Inferred from mutant phenotype
17114484 MGI
involved in positive regulation of inflammatory response IMP
IMP: Inferred from mutant phenotype
17114484 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

programmed cell death protein 4

  • protein MA-3

  • topoisomerase-inhibitor suppressed protein

Pdcd4 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Pdcd4 Q61823 Eif4g2 Mus musculus Q62448
Pull Down
12482958
Intra
Pdcd4 Q61823 Eif4a1 Mus musculus P60843
ITC
19153607
Intra
Pdcd4 Q61823 Eif4a1 Mus musculus P60843
X-Ray Diffraction
19153607
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (7)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-145232 PhosTAC7 99.23% Unkown
HY-153383 PDCD4-IN-1 Inhibitor 99.41% Unkown
HY-148509 PhosTAC5 98.02% Unkown
HY-148508 PhosTAC3 Inhibitor 99.97% Unkown
HY-RS10192 PDCD4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17345 Pdcd4 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23799 Pdcd4 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Pdcd4 NCBI NCBI:27250