Eif4g2 - eukaryotic translation initiation factor 4, gamma 2 Gene

Also Known as p97; Nat1; DAP-5; Natm1; E130105L11Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 13690

Summary

Translation initiation is mediated by specific recognition of the cap structure by eukaryotic translation initiation factor 4F (eIF4F), which is a cap binding protein complex that consists of three subunits: eIF4A, eIF4E and eIF4G. The protein encoded by this gene shares similarity with the C-terminal region of eIF4G, that contains the binding sites for eIF4A and eIF3; eIF4G in addition, contains a binding site for eIF4E at the N-terminus. Unlike eIF4G which supports cap-dependent and independent translation, this gene product functions as a general repressor of translation by forming translationally inactive complexes. Transgene expression of the Apolipoprotein B mRNA-editing enzyme (APOBEC-1) causes extensive editing of this mRNA, which could contribute to the potent oncogenesis induced by overexpression of APOBEC-1. In vitro and in vivo studies in human indicate that translation of this mRNA initiates exclusively at a non-AUG (GUG) codon. This also appears to be true for mouse. Two alternatively spliced transcript variants that encode different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Eif4g2 Products (2)

mRNA Protein Name
NM_001040131.2 NP_001035221.1 eukaryotic translation initiation factor 4 gamma 2 isoform 2
NM_013507.3 NP_038535.2 eukaryotic translation initiation factor 4 gamma 2 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
12482958 MGI
enables translation initiation factor activity IDA
IDA: Inferred from direct assay
9030685 MGI
Biological Process GO Annotation Evidence References Source
involved in regulation of translational initiation IDA
IDA: Inferred from direct assay
9030685 MGI
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
12388085 MGI
is active in postsynaptic density EXP
EXP: Inferred from Experiment
25211037 MGI
is active in postsynaptic density IDA
IDA: Inferred from direct assay
25211037 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

eukaryotic translation initiation factor 4 gamma 2

  • eIF-4-gamma 2

  • eIF-4G 2

  • eIF4G 2

  • novel APOBEC-1 target 1

  • translation repressor Nat1

Eif4g2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Eif4g2 Q62448 Pdcd4 Mus musculus Q61823
Pull Down
12482958
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS04282 EIF4G2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Eif4g2 NCBI NCBI:1982