PMCH - pro-melanin concentrating hormone Gene

Also Known as MCH; ppMCH

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 5367

About PMCH

Cytogenetic location: 12q23.2 Genomic coordinates (GRCh38): 12:102,196,459-102,197,833 (from NCBI)

This gene has 1 transcript (splice variant) and 190 orthologues. Broad expression in bone marrow (RPKM 1.1), lymph node (RPKM 0.9) and 21 other tissues.

Summary

This gene encodes a preproprotein that is proteolytically processed to generate multiple protein products. These products include melanin-concentrating hormone (MCH), neuropeptide-glutamic acid-isoleucine (NEI), and neuropeptide-glycine-glutamic acid (NGE). Melanin-concentrating hormone is a 19-amino acid neuropeptide that stimulates hunger and may additionally regulate energy homeostasis, reproductive function, and sleep. Pseudogenes of this gene have been identified on chromosome 5. [provided by RefSeq, Jul 2015]

PMCH Products (1)

mRNA Protein Name
NM_002674.4 NP_002665.2 pro-MCH preproprotein

PMCH Protein Structure

Pro-MCH

Pro-MCH: Pro-melanin-concentrating hormone (Pro-MCH) (80 - 165)

  • 0
  • 100
  • 165 a.a.
Protein Preferred Names Protein Names

pro-MCH

  • prepro-MCH

Related Diseases

Diseases Alias
Epilepsy, Familial Temporal Lobe, 5

  • Familial Temporal Lobe Epilepsy 5

  • ETL5

  • Epilepsy, Temporal Lobe, Familial, Type 5
Huntington Disease

  • Huntington'S Disease

  • Huntington Chorea

  • Huntington'S Chorea

  • HD

  • Huntington Chronic Progressive Hereditary Chorea

  • Juvenile Huntington Disease

  • Chronic Progressive Chorea

  • Chronic Progressive Hereditary Chorea

  • Hc - [Huntington Chorea]

  • Hereditary Chorea

  • Progressive Hereditary Chorea
Stormorken Syndrome

  • Thrombocytopathy, Asplenia, And Miosis

  • Stormorken-Sjaastad-Langslet Syndrome

  • STRMK

  • York Platelet Syndrome

  • Yps

  • Thrombocytopathy, Asplenia And Miosis

  • Thrombocytopathy Asplenia Miosis

  • Thrombocytopathy-Asplenia-Miosis Syndrome

  • Miosis Disorder
Cartilage-Hair Hypoplasia

  • Metaphyseal Chondrodysplasia, Mckusick Type

  • CHH

  • Mckusick Type Metaphyseal Chondrodysplasia

  • Metaphyseal Dysplasia Without Hypotrichosis

  • Cartilage Hair Hypoplasia Like Syndrome

  • Metaphyseal Chondrodysplasia Mckusick Type

  • Chhv

  • Cartilage-Hair Hypoplasia Variant, Skeletal Manifestations Only

  • Cartilage-Hair Hypoplasia-Like Skeletal Dysplasia Without Hypotrichosis Or Immunodeficiency

  • Cartilage-Hair Syndrome

  • Mckusick'S Metaphyseal Chondrodysplasia Syndrome

  • Metaphyseal Chondrodysplasia, Recessive Type

  • Autosomal Recessive Metaphyseal Chondrodysplasia
Body Mass Index Quantitative Trait Locus 11

  • OBESITY

  • Obesity, Susceptibility To

  • Leanness, Inherited

  • Obesity, Susceptibility To, Bmiq11

  • Obesity, Mild, Early-Onset

  • Obesity, Association With

  • Obesity, Early-Onset, Susceptibility To

  • Obesity, Severe

  • Obesity, Severe, And Type Ii Diabetes

  • Obesity, Late-Onset

  • Obesity , Susceptibility To

  • BMIQ11

  • Obesity Bmiq11

  • Obesity, Early-Onset

  • Simple Obesity Nos

  • Excess Fat

  • Obesity, Not Elsewhere Classified, Body Mass Index Not Elsewhere Classified

  • Adiposis
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS10759 PMCH Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22282 Pmch Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28805 Pmch Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus PMCH VGNC VGNC:33068
Canis familiaris PMCH VGNC VGNC:44729
Rattus norvegicus PMCH RGD RGD:3358
Mus musculus PMCH MGD MGI:97629
Others PMCH NCBI