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TECR - trans-2,3-enoyl-CoA reductase Gene

Also Known as SC2; TER; GPSN2; MRT14

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 9524

About TECR

Cytogenetic location: 19p13.12 Genomic coordinates (GRCh38): 19:14,527,726-14,565,980 (from NCBI)

This gene has 26 transcripts (splice variants), 268 orthologues, 3 paralogues and is associated with 2 phenotypes. Ubiquitous expression in esophagus (RPKM 95.3), skin (RPKM 93.5) and 25 other tissues.

Summary

This gene encodes a multi-pass membrane protein that resides in the endoplasmic reticulum, and belongs to the steroid 5-alpha reductase family. The elongation of microsomal long and very long chain fatty acid consists of 4 sequential reactions. This protein catalyzes the final step, reducing trans-2,3-enoyl-CoA to saturated acyl-CoA. Alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Apr 2011]

TECR Products (2)

mRNA	Protein	Name
NM_001321170.1	NP_001308099.1	very-long-chain enoyl-CoA reductase isoform 2
NM_138501.6	NP_612510.1	very-long-chain enoyl-CoA reductase isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA
enables very-long-chain enoyl-CoA reductase activity	IDA IDA: Inferred from direct assay	12482854	GOA
enables very-long-chain enoyl-CoA reductase activity	IMP IMP: Inferred from mutant phenotype	24220030	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in fatty acid elongation	IDA IDA: Inferred from direct assay	12482854	GOA
involved in sphingolipid metabolic process	IMP IMP: Inferred from mutant phenotype	25049234	GOA
involved in very long-chain fatty acid biosynthetic process	IDA IDA: Inferred from direct assay	12482854	GOA
involved in very long-chain fatty acid biosynthetic process	IMP IMP: Inferred from mutant phenotype	24220030	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in endoplasmic reticulum	IDA IDA: Inferred from direct assay	24220030	GOA
located in endoplasmic reticulum membrane	IDA IDA: Inferred from direct assay	12482854	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TECR Protein Structure

Steroid_dh

0
100
200
308 a.a.

Protein Preferred Names	Protein Names
very-long-chain enoyl-CoA reductase	epididymis secretory sperm binding protein

TECR Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	TECR	Q9NZ01	RETREG3	Homo sapiens	Q86VR2	Y2H Prey Pooling	32296183
Intra	TECR	Q9NZ01	RETREG3	Homo sapiens	Q86VR2	Y2H Array	32296183
Intra	TECR	Q9NZ01	JAGN1	Homo sapiens	Q8N5M9	Y2H Array	32296183
Intra	TECR	Q9NZ01	JAGN1	Homo sapiens	Q8N5M9	Y2H Prey Pooling	32296183
Intra	TECR	Q9NZ01	TFAM	Homo sapiens	Q00059	Y2H Array	32296183
Intra	TECR	Q9NZ01	TFAM	Homo sapiens	Q00059	Y2H Prey Pooling	32296183
Intra	TECR	Q9NZ01	PGRMC2	Homo sapiens	O15173	Y2H Prey Pooling	32296183
Intra	TECR	Q9NZ01	PGRMC2	Homo sapiens	O15173	Y2H Array	32296183
Intra	TECR	Q9NZ01	VMA21	Homo sapiens	Q3ZAQ7	Y2H Array	32296183
Intra	TECR	Q9NZ01	VMA21	Homo sapiens	Q3ZAQ7	Y2H Prey Pooling	32296183
Intra	TECR	Q9NZ01	ARL13B	Homo sapiens	Q3SXY8	Y2H Prey Pooling	32296183
Intra	TECR	Q9NZ01	ARL13B	Homo sapiens	Q3SXY8	Y2H Array	32296183
Intra	TECR	Q9NZ01	HACD1	Homo sapiens	B0YJ81	Y2H Prey Pooling	32296183
Intra	TECR	Q9NZ01	HACD1	Homo sapiens	B0YJ81	Y2H Array	32296183
Intra	TECR	Q9NZ01	STOM	Homo sapiens	P27105	Y2H Prey Pooling	32296183
Intra	TECR	Q9NZ01	STOM	Homo sapiens	P27105	Y2H Array	32296183
Intra	TECR	Q9NZ01	GOLT1A	Homo sapiens	Q6ZVE7	Y2H Prey Pooling	32296183
Intra	TECR	Q9NZ01	GOLT1A	Homo sapiens	Q6ZVE7	Y2H Array	32296183
Intra	TECR	Q9NZ01	CRB3	Homo sapiens	Q9BUF7-2	Y2H Array	32296183
Intra	TECR	Q9NZ01	CRB3	Homo sapiens	Q9BUF7-2	Y2H Prey Pooling	32296183
Intra	TECR	Q9NZ01	MUC1	Homo sapiens	P15941-11	Y2H Prey Pooling	32296183
Intra	TECR	Q9NZ01	MUC1	Homo sapiens	P15941-11	Y2H Array	32296183
Intra	TECR	Q9NZ01	SLC10A6	Homo sapiens	Q3KNW5	Y2H Prey Pooling	32296183
Intra	TECR	Q9NZ01	SLC10A6	Homo sapiens	Q3KNW5	Y2H Array	32296183
Intra	TECR	Q9NZ01	FAM209A	Homo sapiens	Q5JX71	Y2H Array	32296183
Intra	TECR	Q9NZ01	FAM209A	Homo sapiens	Q5JX71	Y2H Prey Pooling	32296183
Intra	TECR	Q9NZ01	CLDN5	Homo sapiens	O00501	Y2H Array	32296183
Intra	TECR	Q9NZ01	CLDN5	Homo sapiens	O00501	Y2H Prey Pooling	32296183
Intra	TECR	Q9NZ01	ELOVL4	Homo sapiens	Q9GZR5	Y2H Prey Pooling	32296183
Intra	TECR	Q9NZ01	ELOVL4	Homo sapiens	Q9GZR5	Y2H Array	32296183
Intra	TECR	Q9NZ01	GET1	Homo sapiens	O00258	Y2H Prey Pooling	32296183
Intra	TECR	Q9NZ01	GET1	Homo sapiens	O00258	Y2H Array	32296183
Intra	TECR	Q9NZ01	STING1	Homo sapiens	Q86WV6	Y2H Array	32296183
Intra	TECR	Q9NZ01	STING1	Homo sapiens	Q86WV6	Y2H Prey Pooling	32296183
Intra	TECR	Q9NZ01	MFSD14B	Homo sapiens	Q5SR56	Y2H Prey Pooling	32296183
Intra	TECR	Q9NZ01	MFSD14B	Homo sapiens	Q5SR56	Y2H Array	32296183
Intra	TECR	Q9NZ01	SLC7A14	Homo sapiens	Q8TBB6	Y2H Prey Pooling	32296183
Intra	TECR	Q9NZ01	SLC7A14	Homo sapiens	Q8TBB6	Y2H Array	32296183
Intra	TECR	Q9NZ01	HACD2	Homo sapiens	Q6Y1H2	Crosslink	30021884
Intra	TECR	Q9NZ01	HACD2	Homo sapiens	Q6Y1H2	Y2H Prey Pooling	25416956
Intra	TECR	Q9NZ01	HACD2	Homo sapiens	Q6Y1H2	Y2H Array	25416956
Intra	TECR	Q9NZ01	HACD2	Homo sapiens	Q6Y1H2	Validated Y2H	25416956
Intra	TECR	Q9NZ01	MMGT1	Homo sapiens	Q8N4V1	Y2H Prey Pooling	32296183
Intra	TECR	Q9NZ01	MMGT1	Homo sapiens	Q8N4V1	Y2H Array	32296183
Intra	TECR	Q9NZ01	CREB3L1	Homo sapiens	Q96BA8	Y2H Prey Pooling	32296183
Intra	TECR	Q9NZ01	CREB3L1	Homo sapiens	Q96BA8	Y2H Array	32296183
Intra	TECR	Q9NZ01	CD79A	Homo sapiens	P11912	Y2H Array	32296183
Intra	TECR	Q9NZ01	CD79A	Homo sapiens	P11912	Y2H Prey Pooling	32296183
Intra	TECR	Q9NZ01	ERGIC3	Homo sapiens	Q9Y282	Y2H Prey Pooling	32296183
Intra	TECR	Q9NZ01	ERGIC3	Homo sapiens	Q9Y282	Validated Y2H	32296183
Intra	TECR	Q9NZ01	ERGIC3	Homo sapiens	Q9Y282	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Intellectual Developmental Disorder, Autosomal Recessive 14	MRT14 Mental Retardation, Autosomal Recessive 14 Autosomal Recessive Intellectual Developmental Disorder 14 Mental Retardation, Autosomal Recessive, Type 14
Autosomal Recessive Non-Syndromic Intellectual Disability	Ar-Nsid Ns-Arid
Seborrheic Infantile Dermatitis	Cradle Cap Infantile Seborrhoeic Dermatitis Seborrhoea Capitis Seborrhoeic Dermatitis Of Scalp Seborrhoeic Eczema Of Scalp Complement 5 Dysfunction Generalized Seborrheic Dermatitis Of Infants Infantile Seborrheic Dermatitis Pityriasis Capitis Seborrhea Capitis Seborrhea Sicca Dandruff Complement Component 5 Deficiency Seborrheic Dermatitis Seborrheic Dermatitis Of Scalp Scurfiness Of Scalp Seborrheic Dermatitis Of Infancy Infantile Seborrhoeic Eczema Neonatal Seborrhoeic Dermatitis Infantile Seborrhoeic Dermatitis Of The Scalp
Cataract 24	CTRCT24 Cataract 24, Anterior Polar Cataract, Anterior Polar, 2 Ctaa2 Anterior Polar Cataract 2 Early-Onset Anterior Polar Cataract Early-Onset Anterior Subcapsular Cataract Anterior Polar Cataract 24 Cataract Anterior Polar Cataract, Anterior Polar-2 Cataract, Anterior Polar
Tongue Carcinoma	Tongue Cancer Malignant Neoplasm Of Tongue Tongue Neoplasms Tongue Neoplasm
Oral Mucosa Leukoplakia	Leukoplakia, Oral Leukoplakia Of Buccal Mucosa
Spindle Cell Hemangioma	Sch Spindle Cell Hemangioendothelioma
Autosomal Recessive Intellectual Developmental Disorder	Mental Retardation, Autosomal Recessive Autosomal Recessive Mental Retardation Autosomal Recessive Non-Syndromic Mental Retardation Autosomal Recessive Non-Syndromic Intellectual Disability

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14349	TECR Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS22342	Tecr Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS28864	Tecr Rat Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	TECR	VGNC	VGNC:80732
Macaca mulatta	TECR	VGNC	VGNC:103877
Canis familiaris	TECR	VGNC	VGNC:47234
Rattus norvegicus	TECR	RGD	RGD:620376
Bos taurus	TECR	VGNC	VGNC:35730
Mus musculus	TECR	MGD	MGI:1915408
Others	TECR	NCBI