Lipustobart
Based on 1 Customer Validation
Lipustobart (LZM-009) is a PD-1 inhibitor that binds to PD-1 and blocks the PD-1/PD-L1 interaction. Lipustobart also binds to FcRn and FcγRI. Lipustobart can be used in research on colon cancer.
For research use only. We do not sell to patients.
- Purity : 99.9%
- CAS No.: 2639481-06-2
- Molecular Weight:146.101 kDa
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Storage:Shipping with dry ice
Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
Description
Isotype
Human IgG4 kappa
Recommend Isotype Controls
Species Reactivity
Human
IC50 & Target
[1]|
PD-1 |
PD-L1 |
FcRn |
FcγRI |
In Vitro
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Subcutaneous MC38 colon cancer model in hPD-1 transgenic mice[1]
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Dosage:1 mg/kg
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Administration:i.v.; days 10 and 17 after tumor cell inoculation
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Result:Inhibited tumor growth, with 6 out of 9 subjects achieving complete remission.
Gene ID
Accession
Conjugated
Unconjugated
Reconsititution
The product can be reconstituted/diluted with sterile PBS or saline.
Format
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Human IgG4 kappa
Application
ELISA, FACS, Functional assay
Verified Bioactivity
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Immobilized PD-1 Protein, Human (HEK293, His, HY-P7396) can bind Lipustobart. The EC50 for this effect is 1.21 ng/mL.
Chemical Information
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CAS No. 2639481-06-2
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Appearance Liquid
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Molecular Weight 146.101 kDa
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Color Colorless to light yellow
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SMILES
[Lipustobart]
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Synonyms
LZM-009
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Shipping
Shipping with dry ice.
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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Data Sheet (271 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
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Inhibitory Antibodies User Guide (603 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)