MI 63
MI 63 is an activator for p53, by targeting the MDM2 (Ki is 3 nM). MI 63 inhibits the proliferation of embryonic and alveolar rhabdomyosarcoma (ERMS and ARMS) cells (IC50 is 0.58 μM in RH36 cells), and induces apoptosis in ERMS and ARMS.
For research use only. We do not sell to patients.
- CAS No.: 908027-21-4
- Formula: C29H35Cl2FN4O3
- Molecular Weight:577.52
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A2780 | GI50 |
1.19 μM
Compound: 2a, MI-63
|
Growth inhibition of human A2780 cells expressing MDM2 by SRB assay
Growth inhibition of human A2780 cells expressing MDM2 by SRB assay
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[PMID: 21875801] |
| HCT-116 | GI50 |
1.3 μM
Compound: 2a, MI-63
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Growth inhibition of human HCT116 cells expressing MDM2 by SRB assay
Growth inhibition of human HCT116 cells expressing MDM2 by SRB assay
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[PMID: 21875801] |
| HCT-116 | GI50 |
11.8 μM
Compound: 2a, MI-63
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Growth inhibition of p53 deficient human HCT116 cells expressing MDM2 by SRB assay
Growth inhibition of p53 deficient human HCT116 cells expressing MDM2 by SRB assay
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[PMID: 21875801] |
| HCT-116 | IC50 |
0.7 μM
Compound: 1, MI-63
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Growth inhibition of human HCT116 cells expressing wild type p53 gene after 4 days by WST8 dye reduction assay
Growth inhibition of human HCT116 cells expressing wild type p53 gene after 4 days by WST8 dye reduction assay
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[PMID: 19928922] |
| HCT-116 | IC50 |
14.4 μM
Compound: 1, MI-63
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Growth inhibition of human HCT116 cells deficient in p53 gene expression after 4 days by WST8 dye reduction assay
Growth inhibition of human HCT116 cells deficient in p53 gene expression after 4 days by WST8 dye reduction assay
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[PMID: 19928922] |
| LNCaP | IC50 |
280 nM
Compound: 8, MI-63
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Antiproliferative activity against human LnCAP cell line with wild type p53
Antiproliferative activity against human LnCAP cell line with wild type p53
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[PMID: 16759082] |
| PC-3 | IC50 |
18 μM
Compound: 8, MI-63
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Antiproliferative activity against human PC3 cell line with deleted p53
Antiproliferative activity against human PC3 cell line with deleted p53
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[PMID: 16759082] |
| SAOS-2 | IC50 |
14.1 μM
Compound: 1, MI-63
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Growth inhibition of human Saos2 cells deficient in p53 gene expression after 4 days by WST8 dye reduction assay
Growth inhibition of human Saos2 cells deficient in p53 gene expression after 4 days by WST8 dye reduction assay
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[PMID: 19928922] |
| SJSA-1 | GI50 |
0.55 μM
Compound: 2a, MI-63
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Growth inhibition of human SJSA1 cells expressing MDM2 by SRB assay
Growth inhibition of human SJSA1 cells expressing MDM2 by SRB assay
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[PMID: 21875801] |
| SJSA-1 | IC50 |
0.5 μM
Compound: 1, MI-63
|
Growth inhibition of human SJSA1 cells expressing wild type p53 gene after 4 days by WST8 dye reduction assay
Growth inhibition of human SJSA1 cells expressing wild type p53 gene after 4 days by WST8 dye reduction assay
|
[PMID: 19928922] |
Chemical Information
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CAS No. 908027-21-4
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Molecular Weight 577.52
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Formula C29H35Cl2FN4O3
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SMILES
O=C([C@H](N[C@@H]1CC(C)(C)C)[C@H](C2=CC=CC(Cl)=C2F)[C@]31C(NC4=C3C=CC(Cl)=C4)=O)NCCN5CCOCC5
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
MI 63 Related Classifications
HY-18330 Related Classifications
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