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Cat. No.: HY-156465

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RIOK2-IN-2

RIOK2-IN-2 (8) is a RIOK2 inhibitor, with IC₅₀ values of 3.02 μM and 5.34 μM in MKN-1 and MOLT4 cells, respectively.

For research use only. We do not sell to patients.

CAS No.: 2648987-17-9
Formula: C₂₇H₂₃F₃N₆O₂
Molecular Weight:520.51

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (275 KB)

RIOK2-IN-2 Chemical Structure

CAS No.: 2648987-17-9

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- Cellular Effect
Chemical Information
Protocols (1)
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

RIOK2-IN-2 (8) is a RIOK2 inhibitor, with IC₅₀ values of 3.02 μM and 5.34 μM in MKN-1 and MOLT4 cells, respectively^[1].

IC₅₀ & Target

RIOK2

Cellular Effect

Cell Line	Type	Value	Description	References
MKN-1	IC₅₀	1.05 μM Compound: 9	Antiproliferative activity against human MKN-1 cells assessed as inhibition of cell proliferation by CCK8 assay Antiproliferative activity against human MKN-1 cells assessed as inhibition of cell proliferation by CCK8 assay	[PMID: 37859717]
MOLT-4	IC₅₀	1.57 μM Compound: 9	Antiproliferative activity against human MOLT-4 cells assessed as inhibition of cell proliferation by CCK8 assay Antiproliferative activity against human MOLT-4 cells assessed as inhibition of cell proliferation by CCK8 assay	[PMID: 37859717]
U-87MG ATCC	IC₅₀	1.25 μM Compound: 9	Antiproliferative activity against human U-87 MG cells assessed as inhibition of cell proliferation by CCK8 assay Antiproliferative activity against human U-87 MG cells assessed as inhibition of cell proliferation by CCK8 assay	[PMID: 37859717]

Chemical Information

CAS No. 2648987-17-9
Molecular Weight 520.51
Formula C₂₇H₂₃F₃N₆O₂
SMILES

O=C1NC2=CC=C(C3=CC=C(OC)N=C3)C=C2C4=C1C=NN4C5=CC=C(N6CCNCC6)C(C(F)(F)F)=C5
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Protocols

All Cell Biology

Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (275 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Huilan Xiong, et al. Exploration of tricyclic heterocycles as core structures for RIOK2 inhibitors. RSC Med Chem. 2023 Jul 21;14(10):2007-2011. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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