ORL1 antagonist 1
Based on 1 Customer Validation
ORL1 antagonist 1 is an opioid receptor-like 1 (ORL1) antagonist with an IC50 of 61 nM.
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- Pureté : 96.29%
- CAS No.: 1174985-59-1
- Formule: C20H22ClN5
- Masse moléculaire:367.88
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Stockage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Activité biologique
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Chemical Information
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Solvant et solubilité
- Protocole
- Pureté et documentation
- Références
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Help & FAQs
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Activité biologique
Description
IC50 & Target
IC50: 61 nM (ORL1)[1]
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HEK293 | IC50 |
23 μM
Compound: 17
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Displacement of [35S]MK499 from human ERG expressed in HEK293 cells
Displacement of [35S]MK499 from human ERG expressed in HEK293 cells
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[PMID: 19447610] |
In Vitro
ORL1 antagonist 1 is compound 17[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
Chemical Information
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CAS No. 1174985-59-1
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Appearance Solid
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Masse moléculaire 367.88
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Formule C20H22ClN5
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Color White to light yellow
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SMILES
CC1=C(C2=CC=CN=C2)N(C3=NC=CC=C3Cl)N=C1CNC4CCCC4
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Solvant et solubilité
In Vitro:
DMSO : 25 mg/mL (67.96 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Protocole
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
Pureté et documentation
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Fiche technique (274 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Instruction de manipulation (2659 KB)
Références
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.7183 mL | 13.5914 mL | 27.1828 mL | 67.9569 mL |
| 5 mM | 0.5437 mL | 2.7183 mL | 5.4366 mL | 13.5914 mL | |
| 10 mM | 0.2718 mL | 1.3591 mL | 2.7183 mL | 6.7957 mL | |
| 15 mM | 0.1812 mL | 0.9061 mL | 1.8122 mL | 4.5305 mL | |
| 20 mM | 0.1359 mL | 0.6796 mL | 1.3591 mL | 3.3978 mL | |
| 25 mM | 0.1087 mL | 0.5437 mL | 1.0873 mL | 2.7183 mL | |
| 30 mM | 0.0906 mL | 0.4530 mL | 0.9061 mL | 2.2652 mL | |
| 40 mM | 0.0680 mL | 0.3398 mL | 0.6796 mL | 1.6989 mL | |
| 50 mM | 0.0544 mL | 0.2718 mL | 0.5437 mL | 1.3591 mL | |
| 60 mM | 0.0453 mL | 0.2265 mL | 0.4530 mL | 1.1326 mL |
ORL1 antagonist 1 Related Classifications
HY-112263 Related Classifications
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