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Cat. No.: HY-120484

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A-1048400

A-1048400 is an orally active and selective calcium channel inhibitor with an IC₅₀ value of 1.4 μM for N-type channels, 1.2 μM for T-type channel. A-1048400 inhibits neurotransmitter release and reduces membrane hyperexcitability, exerting potent analgesic activity. A-1048400 is promising for research of neuropathic pain (e.g., pain induced by spinal nerve ligation and chronic constriction injury).

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CAS No.: 1219624-62-0
Formule: C₃₆H₃₇N₃O₂
Masse moléculaire:543.70

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Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

A-1048400 Chemical Structure

CAS No.: 1219624-62-0

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

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Description

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Chemical Information

CAS No. 1219624-62-0
Masse moléculaire 543.70
Formule C₃₆H₃₇N₃O₂
SMILES

O=C1N(CC(N2CCN(C(C3=CC=CC=C3)C4=CC=CC=C4)CC2)=O)CCCC1(C5=CC=CC=C5)C6=CC=CC=C6
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

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Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (269 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Scott VE, et al. A-1048400 is a novel, orally active, state-dependent neuronal calcium channel blocker that produces dose-dependent antinociception without altering hemodynamic function in rats. Biochem Pharmacol. 2012 Feb 1;83(3):406-18. [Content Brief]

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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A-1048400

Voir tous les produits spécifiques à Isoform Calcium Channel

Activité biologique

Chemical Information

Pureté et documentation

Références

Calculators

Help & FAQs

A-1048400 Related Classifications

HY-120484 Related Classifications