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Cat. No.: HY-184782

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α-Synuclein-IN-19

α-Synuclein-IN-19 is a polyphenolic acid monoamide derivative and an inhibitor of α-synuclein (α-Syn) aggregation. α-Synuclein-IN-19 can be used in Parkinson's disease-related research.

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CAS No.: 1026937-99-4
Formule: C₁₅H₁₄N₂O₃
Masse moléculaire:270.29

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

α-Synuclein-IN-19 Chemical Structure

CAS No.: 1026937-99-4

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- In Vitro
Chemical Information
Protocole (1)
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

α-Synuclein-IN-19 is a polyphenolic acid monoamide derivative and an inhibitor of α-synuclein (α-Syn) aggregation. α-Synuclein-IN-19 can be used in Parkinson's disease-related research^[1].

Voir tous les produits spécifiques à Isoform α-synuclein :

In Vitro

α-Synuclein-IN-19 (compound 2e) (30 μM; 72 h) inhibits α-Syn aggregation in vitro with an 88.9% aggregation inhibition ratio^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.

Chemical Information

CAS No. 1026937-99-4
Masse moléculaire 270.29
Formule C₁₅H₁₄N₂O₃
SMILES

C(=C/C(NC1=CC=C(N)C=C1)=O)\C2=CC(O)=C(O)C=C2
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Protocole

All Cell Biology

Human pluripotent stem cell midbrain dopaminergic neuron differentiation
Human pluripotent stem cells are directed toward midbrain dopaminergic neurons by first inducing a neural floor-plate-like progenitor state, then patterning cells with ventralizing SHH signaling and midbrain/WNT-FGF cues, and finally maturing progenitors into neurons expressing dopaminergic markers such as TH, NURR1/NR4A2, PITX3, DAT/SLC6A3, VMAT2/SLC18A2, GIRK2/KCNJ6, FOXA2, LMX1A, and EN1. The main readouts are loss of pluripotency, acquisition of FOXA2+/LMX1A+ midbrain floor-plate progenitors, emergence of βIII-tubulin+/MAP2+ neurons, and production of TH+ dopaminergic neurons with molecular, dopamine-release, and electrophysiological features of midbrain dopaminergic identity.

Pureté et documentation

Instruction de manipulation (2659 KB)

Références

[1]. Lü MH, et al. Hybrids of polyphenolic/quinone acids, the potential preventive and therapeutic drugs for PD: Disaggregate α-Syn fibrils, inhibit inclusions, and repair damaged neurons in mice. European journal of medicinal chemistry. 2023 Mar 05;249:115122. [Content Brief]

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Calculateur de dilution

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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