Anticancer agent 227
Anticancer agent 227 (compound YNU-1c) is a potent anticancer agent. Anticancer agent 227 shows antiproliferative activity. Anticancer agent 227 induces apoptosis and mitophagy.
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- Formule: C38H27Cl5N2O2PRh
- Masse moléculaire:854.78
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Protocole
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
Description
In Vitro
Anticancer agent 227 (compound YNU-1c) (0-50 µM; 48 h) shows antiproliferative activity with IC50s of 0.19, 0.13, >50 µM for HepG2, HCC1806, HL-7702 cells, respectively[1].
Anticancer agent 227 (0.13 µM; 48 h) induces apoptosis by increasing the expression of cytochrome c and cleaved caspase-3[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HepG2, HCC1806, HL-7702, SF1, SF2 cells
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Concentration:0-50 μM
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Incubation Time:48 h
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Result:Showed antiproliferative activity with IC50s of 0.19, 0.13, >50, >384.6, >263.2 μM for HepG2, HCC1806, HL-7702, SF1, SF2 cells, respectively.
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Cell Line:HCC1806 cells
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Concentration:0.13 µM
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Incubation Time:48 h
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Result:Upregulated the expression of cytochrome c and cleaved caspase-3.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Balb/c nude mice (HCC1806 cells)[1]
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Dosage:5 mg/kg
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Administration:I.p.; every 2 days for 21 days
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Result:Effectively inhibited HCC1806 tumor growth, reduced tumor weight with a tumor growth inhibition rate of 58.9 %.
Chemical Information
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Masse moléculaire 854.78
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Formule C38H27Cl5N2O2PRh
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SMILES
Cl[Rh]1([P](C2=CC=CC=C2)(C3=CC=CC=C3)C4=CC=CC=C4)OC5=C6C(C=CC(C)=[N]61)=C(Cl)C=C5Cl.[2]
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
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Fiche technique (273 KB)
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SDS (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Instruction de manipulation (2659 KB)
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Anticancer agent 227 Related Classifications
HY-163619 Related Classifications
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