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Cat. No.: HY-14767

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Fasobegron

Fasobegron is a β₃-adrenergic receptor agonist with a human EC₅₀ of 4.8 nM. Fasobegron shows an EC₅₀ of 250 nM for human β₁-adrenergic receptors. Fasobegron can be used for the research of overactive bladder.

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CAS No.: 643094-49-9
Formule: C₂₄H₂₄ClNO₄
Masse moléculaire:425.91

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Fasobegron Chemical Structure

CAS No.: 643094-49-9

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- IC₅₀ & Target
- Cellular Effect
- In Vitro
Chemical Information
Pureté et documentation
Références
Calculators
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Activité biologique

Description

IC₅₀ & Target^[1]

β3 adrenoceptor

4.8 nM (EC₅₀)

β1 adrenoceptor

250 nM (EC₅₀)

Voir tous les produits spécifiques à Isoform Adrenergic Receptor :

Cellular Effect

Cell Line	Type	Value	Description	References
CHO	EC₅₀	>1 μM Compound: 1a	Agonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassay Agonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassay	[PMID: 19366244]
CHO	EC₅₀	>1 μM Compound: 9d	Agonist activity at human beta2 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIA Agonist activity at human beta2 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIA	[PMID: 18307290]
CHO	EC₅₀	250 nM Compound: 1a	Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassay Agonist activity at human recombinant beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassay	[PMID: 19366244]
CHO	EC₅₀	251 nM Compound: 9d	Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIA Agonist activity at human beta-1 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIA	[PMID: 18307290]
CHO	EC₅₀	4.8 nM Compound: 1a	Agonist activity at human recombinant beta3 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassay Agonist activity at human recombinant beta3 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassay	[PMID: 19366244]
CHO	EC₅₀	4.8 nM Compound: 8a	Agonist activity at human recombinant beta3 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assay Agonist activity at human recombinant beta3 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assay	[PMID: 18553954]
CHO	EC₅₀	4.8 nM Compound: 9d	Agonist activity at human beta3 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIA Agonist activity at human beta3 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIA	[PMID: 18307290]

In Vitro

Fasobegron (Compound 1a) potently and selectively activates human β₃-ARs in CHO cells, with an EC₅₀ of 4.8 nM, and exhibits >2000-fold selectivity over human β₂-ARs (EC50 >10000 nM) and ~52-fold selectivity over human β₁-ARs (EC50 = 250 nM)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 643094-49-9
Masse moléculaire 425.91
Formule C₂₄H₂₄ClNO₄
SMILES

O(C)C=1C=C(C=CC1C(O)=O)C2=CC=C(CCNC[C@H](O)C3=CC(Cl)=CC=C3)C=C2
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Instruction de manipulation (2659 KB)

Références

[1]. Hattori K, et al. Discovery of highly potent and selective biphenylacylsulfonamide-based beta3-adrenergic receptor agonists and evaluation of physical properties as potential overactive bladder therapies: part 5. J Med Chem. 2009;52(9):3063-3072. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Activité biologique
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Pureté et documentation
Références

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Fasobegron

Voir tous les produits spécifiques à Isoform Adrenergic Receptor

Activité biologique

Chemical Information

Pureté et documentation

Références

Calculators

Help & FAQs

Fasobegron Related Classifications

HY-14767 Related Classifications