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Cat. No.: HY-182346

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FBPase-IN-7

FBPase-IN-7 is a fructose-1,6-bisphosphatase (FBPase) inhibitor with an IC₅₀ of 0.75 μM. FBPase-IN-7 binds to a cryptic allosteric pocket of FBPase, induces conformational rearrangement of key residues, forms a hydrogen-bond network, and disrupts substrate catalysis. FBPase-IN-7 confirms cellular stabilizes HuFBPase in hepatic cells. FBPase-IN-7 has hypoglycemic activity. FBPase-IN-7 can be used for the research of type 2 diabetes.

Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.

Formule: C₂₃H₁₅F₂N₃O₆S₂
Masse moléculaire:531.51

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

FBPase-IN-7 Chemical Structure

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- In Vitro
- In Vivo
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
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Bioz

Activité biologique

Description

In Vitro

FBPase-IN-7 (Compound 29) potently inhibits purified human fructose-1,6-bisphosphatase (FBPase) with an IC₅₀ of 0.75 μM^[1].
FBPase-IN-7 (20 μM) directly engages HuFBPase in LO2 human liver cells, conferring a thermal stabilization^[1].
FBPase-IN-7 (24 h) shows minimal cytotoxicity in LO2 human liver cells and HEK293T human embryonic kidney cells, with EC₅₀ values >50 μM for both cell lines^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

FBPase-IN-7 (Compound 29) (100 mg/kg; i.p.; single dose) produces meaningful glycemic control in vivo, reducing the 0-1.5 h blood glucose area under the curve by 20.6% in fasted ICR mice subjected to an oral glucose tolerance test^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

ICR mice with glucose challenge (2 g/kg) (male, 20-24 g, 12 h-fasted, oral glucose tolerance test model)^[1]
Dosage:

100 mg/kg
Administration:

i.p.; single dose
Result:

Reduced the blood glucose AUC_0-1.₅ₕ by 20.6%.

Chemical Information

Masse moléculaire 531.51
Formule C₂₃H₁₅F₂N₃O₆S₂
SMILES

O=C(NC1=CC=C(S(NC(NC2=CC=C3OC(F)(OC3=C2)F)=O)(=O)=O)C=C1)C4=CSC5=C4C=CC=C5
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Instruction de manipulation (2659 KB)

Références

[1]. Huang Z, et al. Crystallographic Study Reveals a Cryptic Allosteric Site of FBPase by Sulfonylurea Inhibitors toward T2DM Treatment. J Med Chem. 2026;69(6):7200-7213. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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