MGAT3 - beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase Gene

Also Known as GNT3; GNT-III

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 4248

About MGAT3

Cytogenetic location: 22q13.1 Genomic coordinates (GRCh38): 22:39,457,012-39,492,194 (from NCBI)

This gene has 3 transcripts (splice variants) and 209 orthologues. Broad expression in brain (RPKM 4.5), small intestine (RPKM 3.0) and 17 other tissues.

Summary

There are believed to be over 100 different glycosyltransferases involved in the synthesis of protein-bound and lipid-bound oligosaccharides. The enzyme encoded by this gene transfers a GlcNAc residue to the beta-linked mannose of the trimannosyl core of N-linked oligosaccharides and produces a bisecting GlcNAc. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008]

MGAT3 Products (2)

mRNA Protein Name
NM_001098270.2 NP_001091740.1 beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase
NM_002409.5 NP_002400.3 beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Références Source
enables beta-1,4-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity IMP
IMP: Inferred from mutant phenotype
19403558 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
Biological Process GO Annotation Evidence Références Source
involved in protein localization IMP
IMP: Inferred from mutant phenotype
19403558 GOA
involved in regulation of cell migration IDA
IDA: Inferred from direct assay
26801611 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MGAT3 Protein Structure

Glyco_transf_17

Glyco_transf_17: Glycosyltransferase family 17 (164 - 504)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 533 a.a.
Protein Preferred Names Protein Names

beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase

  • GlcNAc-T III

MGAT3 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Références
Intra
MGAT3 Q09327 UBAC1 Homo sapiens Q9BSL1
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Hepatoblastoma
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Cat. No. Nom du produit Effect
Pureté Phase
HY-138942 PF-06427878 Inhibitor / Phase 1

Pre-clinical Phase

Bioactive Molecules (9)
Cat. No. Nom du produit
Effect
Pureté
Rare Diseases
HY-32219 T863 Inhibitor 99.83% Unkown
HY-103504 (S)-SNAP5114 Inhibitor 98.09% Unkown
HY-108339 PF-06471553 Inhibitor 98.29% Unkown
HY-146280 mGAT3/4-IN-1 Inhibitor / Unkown
HY-146281 mGAT3/4-IN-2 Inhibitor / Unkown
HY-146282 mGAT-IN-1 Inhibitor / Unkown
HY-RS08403 MGAT3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20988 Mgat3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27505 Mgat3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus MGAT3 RGD RGD:3084
Felis catus MGAT3 VGNC VGNC:96703
Bos taurus MGAT3 VGNC VGNC:96698
Mus musculus MGAT3 MGD MGI:104532
Canis familiaris MGAT3 VGNC VGNC:54526
Others MGAT3 NCBI