ATP1B1 - ATPase Na+/K+ transporting subunit beta 1 Gene

Also Known as ATP1B

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 481

About ATP1B1

Cytogenetic location: 1q24.2 Genomic coordinates (GRCh38): 1:169,106,690-169,132,719 (from NCBI)

This gene has 19 transcripts (splice variants), 293 orthologues, 4 paralogues and is associated with 1 phenotype. Broad expression in kidney (RPKM 716.2), brain (RPKM 270.1) and 14 other tissues.

Summary

The protein encoded by this gene belongs to the family of Na+/K+ and H+/K+ ATPases beta chain proteins, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane. The glycoprotein subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes a beta 1 subunit. Alternatively spliced transcript variants encoding different isoforms have been described, but their biological validity is not known. [provided by RefSeq, Mar 2010]

ATP1B1 Products (1)

mRNA	Protein	Name
NM_001677.4	NP_001668.1	sodium/potassium-transporting ATPase subunit beta-1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Références	Source
enables ATPase activator activity	IDA IDA: Inferred from direct assay	10636900	GOA
enables ATPase activator activity	IGI IGI: Inferred from genetic interaction	16861705	GOA
enables ATPase binding	IPI IPI: Inferred from physical interaction	10636900	GOA
enables P-type sodium:potassium-exchanging transporter activity	IDA IDA: Inferred from direct assay	19542013	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	17947299	GOA
enables protein-macromolecule adaptor activity	IDA IDA: Inferred from direct assay	10636900	GOA
enables protein-macromolecule adaptor activity	IGI IGI: Inferred from genetic interaction	16861705	GOA

Biological Process GO Annotation	Evidence	Références	Source
involved in ATP metabolic process	IDA IDA: Inferred from direct assay	23954377	GOA
involved in intracellular potassium ion homeostasis	IDA IDA: Inferred from direct assay	10636900	GOA
involved in intracellular sodium ion homeostasis	IDA IDA: Inferred from direct assay	10636900	GOA
involved in membrane repolarization	IDA IDA: Inferred from direct assay	19542013	GOA
involved in monoatomic cation transmembrane transport	IGI IGI: Inferred from genetic interaction	20100892	GOA
involved in positive regulation of ATP-dependent activity	IDA IDA: Inferred from direct assay	10636900	GOA
involved in positive regulation of P-type sodium:potassium-exchanging transporter activity	IDA IDA: Inferred from direct assay	10636900	GOA
involved in positive regulation of P-type sodium:potassium-exchanging transporter activity	IGI IGI: Inferred from genetic interaction	18728015	GOA
involved in positive regulation of potassium ion import across plasma membrane	IDA IDA: Inferred from direct assay	10636900	GOA
involved in positive regulation of potassium ion import across plasma membrane	IGI IGI: Inferred from genetic interaction	16861705	GOA
involved in positive regulation of potassium ion transmembrane transporter activity	IDA IDA: Inferred from direct assay	10636900	GOA
involved in positive regulation of sodium ion export across plasma membrane	IDA IDA: Inferred from direct assay	10636900	GOA
involved in positive regulation of sodium ion export across plasma membrane	IGI IGI: Inferred from genetic interaction	18728015	GOA
involved in protein localization to plasma membrane	IDA IDA: Inferred from direct assay	18522992	GOA
involved in protein stabilization	IDA IDA: Inferred from direct assay	10636900	GOA
involved in sodium ion export across plasma membrane	IDA IDA: Inferred from direct assay	10636900	GOA
involved in sodium ion transmembrane transport	IGI IGI: Inferred from genetic interaction	16861705	GOA

Cellular Component GO Annotation	Evidence	Références	Source
located in T-tubule	IGI IGI: Inferred from genetic interaction	19751721	GOA
located in apical plasma membrane	IDA IDA: Inferred from direct assay	11193188	GOA
located in lateral plasma membrane	IDA IDA: Inferred from direct assay	11193188	GOA
located in membrane	IDA IDA: Inferred from direct assay	23954377	GOA
located in organelle membrane	IGI IGI: Inferred from genetic interaction	19751721	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	18522992	GOA
located in plasma membrane	IGI IGI: Inferred from genetic interaction	19751721	GOA
part of sodium:potassium-exchanging ATPase complex	IDA IDA: Inferred from direct assay	10636900	GOA
part of sodium:potassium-exchanging ATPase complex	IGI IGI: Inferred from genetic interaction	18728015	GOA
part of sodium:potassium-exchanging ATPase complex	IPI IPI: Inferred from physical interaction	16861705	GOA
located in sperm flagellum	IDA IDA: Inferred from direct assay	16861705	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ATP1B1 Protein Structure

Na_K-ATPase

0
100
200
303 a.a.

Protein Preferred Names	Protein Names
sodium/potassium-transporting ATPase subunit beta-1	ATPase, Na+/K+ transporting, beta 1 polypeptide

ATP1B1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Références
Intra	ATP1B1	P05026	ATP1A1	Homo sapiens	P05023	Anti Tag CoIP	33961781
Intra	ATP1B1	P05026	ATP1A1	Homo sapiens	P05023	Anti Bait CoIP	25012180
Intra	ATP1B1	P05026	AGTR1	Homo sapiens	P30556	Ub Reconstruction	28298427
Intra	ATP1B1	P05026	WFS1	Homo sapiens	O76024	Anti Bait CoIP	17947299
Intra	ATP1B1	P05026	SLC4A1	Homo sapiens	P02730	Pull Down	25012180
Intra	ATP1B1	P05026	SLC4A1	Homo sapiens	P02730	Anti Bait CoIP	25012180
Intra	ATP1B1	P05026	SLC4A1	Homo sapiens	P02730	Y2H	25012180
Intra	ATP1B1	P05026	APP	Homo sapiens	P05067	Validated Y2H	32814053
Intra	ATP1B1	P05026	APP	Homo sapiens	P05067	Y2H Array	32814053
Intra	ATP1B1	P05026	APP	Homo sapiens	P05067	Y2H Pooling	32814053

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant ATP1B1 Proteins

Cat. No.	Nom du produit	Accession	Pureté
HY-P75586	ATP1B1 Protein, Human (HEK293, His)	P05026-1 (E63-S303)	≥ 95%, as determined by reducing SDS-PAGE.

ATP1B1 Anticorps

Cat. No.	Nom du produit	Application	Reactivity
HY-P82339	ATP1B1 Antibody (YA2084)	WB, IHC-P	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Hypertension, Essential	Essential Hypertension Hypertension High Blood Pressure Hypertension, Essential, Susceptibility To Hypertensive Disease Primary Hypertension EHT Hypertension, Salt-Sensitive Essential, Susceptibility To Hyperpiesia Idiopathic Hypertension Hypertensive Disorder Hypertension, Essential, Susceptibility To, 3 Hypertension, Essential 3 Hypertension, Essential, Salt-Sensitive Hypertension, Essential, Susceptibility To, 6 Hypertension, Essential 6 Hypertension, Salt-Sensitive Essential Hypertension, Susceptibility To Hypertension, Essential, Susceptibility To, 4 Hypertension, Essential 4 Hypertension, Essential, Susceptibility To, 2 Hypertension, Essential 2 Hypertension, Essential, Susceptibility To, 1 Hypertension, Essential 1 Hypertension, Essential, Susceptibility To, 5 Hypertension, Essential 5 Htn Vascular Hypertensive Disorder Systemic Primary Arterial Hypertension Hbp - [High Blood Pressure] Systemic Arterial Hypertensive Disorder Elevated Blood Pressure Arterial Hypertension Nos Hypertension Nos Benign Hypertension Systemic Arterial Hypertension Systemic Hypertension Artery Htn Benign Htn Vascular Htn Vascular Hypertension Cholesterol Hypertension Cholesterol Htn Idiopathic Htn Malignant Hypertension Malignant Htn Raised Blood Pressure Cardiovascular Hypertension Primary Htn - [Hypertension] High Arterial Tension High Blood Pressure Disorder Ht - [Hypertension] Htn - [Hypertension] Hypertensive Vascular Disease Hypertensive Vascular Degeneration
Familial Hemiplegic Migraine	Hemiplegic Migraine, Familial Hemiplegic-Ophthalmoplegic Migraine Fhm Hemiplegic Migraine Familial
Petroclival Meningioma
Fibrolamellar Carcinoma	Fibrolamellar Hepatocellular Carcinoma Fhcc Fibrolamellar Hepatocarcinoma Hepatocellular Carcinoma, Fibrolamellar Oncocytic Hepatocellular Tumor Eosinophilic Glassy Cell Hepatoma Eosinophilic Hepatocellular Carcinoma With Lamellar Fibrosis Fl-Hcc Fibrolamellar Oncocytic Hepatoma Hepatocellular Carcinoma With Increased Stromal Fibrosis Polygonal Cell Hepatocellular Carcinoma With Fibrous Stroma
Alternating Hemiplegia Of Childhood	Alternating Hemiplegia Ahc Alternating Hemiplegia Syndrome Hemiplegia, Alternating, Of Childhood Hemiplegia, Crossed
Fuchs' Endothelial Dystrophy	Fuchs Endothelial Corneal Dystrophy Fuchs Endothelial Dystrophy Fuchs Dystrophy Fced Fuchs' Corneal Dystrophy Fuchs' Endothelial Corneal Dystrophy Fuchs Atrophy Fuchs Corneal Dystrophy Endoepithelial Corneal Dystrophy Fecd Late Hereditary Endothelial Dystrophy Corneal Dystrophy, Fuchs Endothelial Dystrophy, Corneal, Fuchs Endothelial Corneal Dystrophy, Fuchs' Endothelial, 1
Amyotrophic Lateral Sclerosis 1	Amyotrophic Lateral Sclerosis ALS Lou Gehrig Disease Amyotrophic Lateral Sclerosis Type 1 Charcot Disease ALS1 Amyotrophic Lateral Sclerosis, Susceptibility To Fals Lou Gehrig'S Disease Mnd Motor Neuron Disease Familial Amyotrophic Lateral Sclerosis Amyotrophic Lateral Sclerosis 1, Familial Amyotrophic Lateral Sclerosis 1, Autosomal Dominant Motor Neuron Disease, Bulbar Motor Neurone Disease Amyotrophic Lateral Sclerosis With Dementia Dementia With Amyotrophic Lateral Sclerosis Motor Neuron Disease, Amyotrophic Lateral Sclerosis Sclerosis, Lateral, Amyotrophic Sclerosis, Lateral, Amyotrophic, Type 1 Amyotrophic Sclerosis Als - [Amyotrophic Lateral Sclerosis] Wasting Palsy Amyotrophic Paralysis Amyotrophy Lateral Sclerosis Wasting Paralysis Spinal Progressive Amyotrophy Progressive Atrophic Paralysis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Nom du produit	Effect	Pureté	Rare Diseases
HY-P1565A	Transdermal Peptide Disulfide TFA	Inhibitor	99.95%	Unkown
HY-P1565	Transdermal Peptide Disulfide	Inhibitor	98.79%	Unkown
HY-RS01186	ATP1B1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS21097	Atp1b1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS27615	Atp1b1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	ATP1B1	VGNC	VGNC:70176
Rattus norvegicus	ATP1B1	RGD	RGD:2170
Canis familiaris	ATP1B1	VGNC	VGNC:38248
Felis catus	ATP1B1	VGNC	VGNC:68583
Bos taurus	ATP1B1	VGNC	VGNC:26285
Mus musculus	ATP1B1	MGD	MGI:88108
Others	ATP1B1	NCBI