RAB17 - RAB17, member RAS oncogene family Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 64284

About RAB17

Cytogenetic location: 2q37.3 Genomic coordinates (GRCh38): 2:237,574,326-237,590,734 (from NCBI)

This gene has 11 transcripts (splice variants), 147 orthologues and 68 paralogues. Biased expression in duodenum (RPKM 20.0), small intestine (RPKM 19.8) and 12 other tissues.

Summary

The Rab subfamily of small GTPases plays an important role in the regulation of membrane trafficking. RAB17 is an epithelial cell-specific GTPase (Lutcke et al., 1993 [PubMed 8486736]).[supplied by OMIM, Oct 2009]

RAB17 Products (1)

mRNA Protein Name
NM_022449.4 NP_071894.1 ras-related protein Rab-17

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Références Source
enables GDP binding IDA
IDA: Inferred from direct assay
20937701 GOA
enables GTPase activity IDA
IDA: Inferred from direct assay
17646400 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
17646400 GOA
Biological Process GO Annotation Evidence Références Source
involved in cilium assembly IMP
IMP: Inferred from mutant phenotype
17646400 GOA
Cellular Component GO Annotation Evidence Références Source
located in endocytic vesicle IDA
IDA: Inferred from direct assay
17646400 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RAB17 Protein Structure

Ras

Ras: Ras family (21 - 181)

  • 0
  • 100
  • 200
  • 212 a.a.
Protein Preferred Names Protein Names

ras-related protein Rab-17

RAB17 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Références
Intra
RAB17 Q9H0T7 FAM9B Homo sapiens Q8IZU0
Y2H Array
25416956
Intra
RAB17 Q9H0T7 FAM9B Homo sapiens Q8IZU0
Validated Y2H
25416956
Intra
RAB17 Q9H0T7 CSTPP1 Homo sapiens Q9H6J7
Y2H Prey Pooling
25416956
Intra
RAB17 Q9H0T7 CSTPP1 Homo sapiens Q9H6J7
Validated Y2H
25416956
Intra
RAB17 Q9H0T7 MAGEA1 Homo sapiens P43355
Validated Y2H
25416956
Intra
RAB17 Q9H0T7 MAGEA1 Homo sapiens P43355
Y2H Array
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Carpenter Syndrome 1

  • Carpenter Syndrome

  • Acrocephalopolysyndactyly Type Ii

  • Acps Ii

  • CRPT1

  • Acrocephalopolysyndactyly Type 2

  • Acrocephalosyndactyly, Type Ii

  • Acrocephalopolysyndactyly 2

  • Acps2

  • Acps 2

  • Type Ii Acrocephalosyndactyly

  • Carpenter Syndrome, Type 1

  • Apert-Crouzon Disease
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Nom du produit
Effect
Pureté
Rare Diseases
HY-RS11525 RAB17 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS29450 Rab17 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta RAB17 VGNC VGNC:81520
Mus musculus RAB17 MGD MGI:104640
Rattus norvegicus RAB17 RGD RGD:1562478
Felis catus RAB17 VGNC VGNC:80333
Bos taurus RAB17 VGNC VGNC:59174
Canis familiaris RAB17 VGNC VGNC:45256
Others RAB17 NCBI