IER3 - immediate early response 3 Gene

Also Known as DIF2; IEX1; PRG1; DIF-2; GLY96; IEX-1; IEX-1L

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 8870

About IER3

Cytogenetic location: 6p21.33 Genomic coordinates (GRCh38): 6:30,743,199-30,744,547 (from NCBI)

This gene has 2 transcripts (splice variants), 1 gene allele and 124 orthologues. Ubiquitous expression in bone marrow (RPKM 75.0), urinary bladder (RPKM 74.3) and 25 other tissues.

Summary

This gene functions in the protection of cells from Fas- or tumor necrosis factor type alpha-induced Apoptosis. Partially degraded and unspliced transcripts are found after virus Infection in vitro, but these transcripts are not found in vivo and do not generate a valid protein. [provided by RefSeq, Jul 2008]

IER3 Products (1)

mRNA Protein Name
NM_003897.4 NP_003888.2 radiation-inducible immediate-early gene IEX-1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Références Source
enables protein binding IPI
IPI: Inferred from physical interaction
15451437 GOA
Biological Process GO Annotation Evidence Références Source
acts upstream of or within DNA damage response IMP
IMP: Inferred from mutant phenotype
20467439 GOA
Cellular Component GO Annotation Evidence Références Source
located in nucleus IDA
IDA: Inferred from direct assay
20467439 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

radiation-inducible immediate-early gene IEX-1

  • PACAP-responsive gene 1 protein

IER3 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Références
Intra
IER3 P46695 CISD2 Homo sapiens Q8N5K1
Y2H Prey Pooling
32296183
Intra
IER3 P46695 CISD2 Homo sapiens Q8N5K1
Validated Y2H
32296183
Intra
IER3 P46695 CISD2 Homo sapiens Q8N5K1
Y2H Array
32296183
Intra
IER3 P46695 TMBIM6 Homo sapiens P55061
Validated Y2H
32296183
Intra
IER3 P46695 PPP2R5C Homo sapiens Q13362
Anti Tag CoIP
16456541
Intra
IER3 P46695 SLC13A4 Homo sapiens Q9UKG4
Validated Y2H
32296183
Intra
IER3 P46695 SLC13A4 Homo sapiens Q9UKG4
Y2H Prey Pooling
32296183
Intra
IER3 P46695 SLC13A4 Homo sapiens Q9UKG4
Y2H Array
32296183
Intra
IER3 P46695 PPP2R5B Homo sapiens Q15173
Anti Tag CoIP
16456541
Intra
IER3 P46695 SGTA Homo sapiens O43765
Y2H Prey Pooling
32296183
Intra
IER3 P46695 SGTA Homo sapiens O43765
Y2H Array
32296183
Intra
IER3 P46695 FKBP7 Homo sapiens Q9Y680
Validated Y2H
32296183
Intra
IER3 P46695 FKBP7 Homo sapiens Q9Y680
Y2H Array
32296183
Intra
IER3 P46695 FKBP7 Homo sapiens Q9Y680
Y2H Prey Pooling
32296183
Intra
IER3 P46695 TMX2 Homo sapiens Q9Y320
Y2H Prey Pooling
32296183
Intra
IER3 P46695 TMX2 Homo sapiens Q9Y320
Validated Y2H
32296183
Intra
IER3 P46695 TMX2 Homo sapiens Q9Y320
Y2H Array
32296183
Intra
IER3 P46695 RELA Homo sapiens Q04206
Anti Tag CoIP
18191642
Intra
IER3 P46695 RELA Homo sapiens Q04206
Pull Down
18191642
Intra
IER3 P46695 RELA Homo sapiens Q04206
Anti Bait CoIP
18191642
Intra
IER3 P46695 CD79A Homo sapiens P11912
Y2H Array
32296183
Intra
IER3 P46695 CD79A Homo sapiens P11912
Y2H Prey Pooling
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

IER3 Anticorps

Cat. No. Nom du produit Application Reactivity
HY-P811299 IEX1 Antibody WB, IHC-P Human, Mouse

Related Diseases

Diseases Alias
Cortical Dysplasia, Complex, With Other Brain Malformations 6

  • Complex Cortical Dysplasia With Other Brain Malformations 6

  • CDCBM6

  • Cdcbm56

  • Dysplasia ,Cortical, Complex, With Other Brain Malformations, Type 6
Pancreatic Ductal Adenocarcinoma

  • Ductal Adenocarcinoma Of The Pancreas
Gilles De La Tourette Syndrome

  • Tourette Syndrome

  • Tourette Disorder

  • GTS

  • Ts

  • Gilles De La Tourette'S Syndrome

  • Motor-Verbal Tic Disorder

  • Guinon'S Disease

  • Psychogenic Tics

  • Tourette'S Syndrome

  • Chronic Motor And Vocal Tic Disorder

  • Td

  • Tourette'S Disease

  • Combined Vocal And Multiple Motor Tic Disorder [De La Tourette]

  • Combined Vocal And Multiple Motor Tic Disorder

  • Tic De La Tourette
Macular Degeneration, Age-Related, 1

  • Macular Degeneration

  • Age-Related Macular Degeneration

  • Macular Degeneration, Age-Related

  • Age Related Macular Degeneration

  • Age Related Macular Degeneration 1

  • ARMD1

  • Senile Macular Degeneration

  • Maculopathy, Age-Related, 1

  • Macular Degeneration, Age-Related, Reduced Risk Of

  • Age Related Maculopathy 1

  • Age Related Maculopathies

  • Age Related Maculopathy

  • Senile Macular Retinal Degeneration

  • Macular Degeneration Of Retina

  • Age-Related Maculopathy

  • Amd

  • Armd

  • Age-Related Maculopathy, Susceptibility To

  • Maculopathy Age-Related

  • Macular Degeneration, Age-Related, 1, Susceptibility To

  • Maculopathy, Age-Related

  • Macular Degeneration, Age-Related, Type 1

  • Macular Degeneration, Age-Related, 2
Kallmann Syndrome

  • Hypogonadism With Anosmia

  • Kallman'S Syndrome

  • Anosmic Hypogonadism

  • Anosmic Idiopathic Hypogonadotropic Hypogonadism

  • Hypogonadotropic Hypogonadism And Anosmia

  • Hypogonadotropic Hypogonadism-Anosmia Syndrome

  • Olfacto-Genital Pathological Sequence

  • Familial Hypogonadism With Anosmia

  • Kallman Syndrome

  • Dysplasia Olfactogenitalis Of De Morsier

  • Kallmann'S Syndrome

  • Congenital Hypogonadotropic Hypogonadism With Anosmia
Dyslexia
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Nom du produit
Effect
Pureté
Rare Diseases
HY-RS06548 IER3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS06549 IER3IP1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19341 Ier3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25832 Ier3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris IER3 VGNC VGNC:57224
Bos taurus IER3 VGNC VGNC:30039
Felis catus IER3 VGNC VGNC:67695
Macaca mulatta IER3 VGNC VGNC:73560
Mus musculus IER3 MGD MGI:104814
Rattus norvegicus IER3 RGD RGD:1303321
Others IER3 NCBI