TCL1B - TCL1 family AKT coactivator B Gene

Also Known as TML1; SYN-1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 9623

About TCL1B

Cytogenetic location: 14q32.13 Genomic coordinates (GRCh38): 14:95,686,426-95,692,628 (from NCBI)

This gene has 3 transcripts (splice variants), 94 orthologues and 2 paralogues. Biased expression in testis (RPKM 1.5), lymph node (RPKM 1.2) and 6 other tissues.

Summary

Enables protein kinase binding activity and protein serine/threonine kinase activator activity. Involved in positive regulation of peptidyl-serine phosphorylation and positive regulation of protein serine/threonine kinase activity. Part of protein-containing complex. [provided by Alliance of Genome Resources, Apr 2022]

TCL1B Products (1)

mRNA Protein Name
NM_004918.4 NP_004909.1 T-cell leukemia/lymphoma protein 1B

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Références Source
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
enables protein kinase binding IPI
IPI: Inferred from physical interaction
10983986 GOA
enables protein serine/threonine kinase activator activity IDA
IDA: Inferred from direct assay
10983986 GOA
Biological Process GO Annotation Evidence Références Source
involved in intracellular signal transduction IDA
IDA: Inferred from direct assay
10983986 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TCL1B Protein Structure

TCL1_MTCP1

TCL1_MTCP1: TCL1/MTCP1 family (1 - 124)

  • 0
  • 100
  • 128 a.a.
Protein Preferred Names Protein Names

T-cell leukemia/lymphoma protein 1B

  • T cell leukemia/lymphoma 1B

TCL1B Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Références
Intra
TCL1B O95988 PLEKHA3 Homo sapiens Q9HB20
Y2H Prey Pooling
32296183
Intra
TCL1B O95988 PLEKHA3 Homo sapiens Q9HB20
Validated Y2H
32296183
Intra
TCL1B O95988 PLEKHA3 Homo sapiens Q9HB20
Y2H Array
32296183
Intra
TCL1B O95988 EFCAB2 Homo sapiens Q5VUJ9-2
Y2H Prey Pooling
32296183
Intra
TCL1B O95988 EFCAB2 Homo sapiens Q5VUJ9-2
Validated Y2H
32296183
Intra
TCL1B O95988 EFCAB2 Homo sapiens Q5VUJ9-2
Y2H Array
32296183
Intra
TCL1B O95988 MEIS3 Homo sapiens Q99687-3
Validated Y2H
32296183
Intra
TCL1B O95988 MEIS3 Homo sapiens Q99687-3
Y2H Prey Pooling
32296183
Intra
TCL1B O95988 MEIS3 Homo sapiens Q99687-3
Y2H Array
32296183
Intra
TCL1B O95988 MKRN3 Homo sapiens Q13064
Validated Y2H
32296183
Intra
TCL1B O95988 MKRN3 Homo sapiens Q13064
Y2H Prey Pooling
32296183
Intra
TCL1B O95988 MKRN3 Homo sapiens Q13064
Y2H Array
32296183
Intra
TCL1B O95988 BAG4 Homo sapiens O95429
Y2H Array
32296183
Intra
TCL1B O95988 BAG4 Homo sapiens O95429
Y2H Prey Pooling
32296183
Intra
TCL1B O95988 PNMA1 Homo sapiens Q8ND90
Validated Y2H
32296183
Intra
TCL1B O95988 PNMA1 Homo sapiens Q8ND90
Y2H Prey Pooling
32296183
Intra
TCL1B O95988 PNMA1 Homo sapiens Q8ND90
Y2H Array
32296183
Intra
TCL1B O95988 LSM7 Homo sapiens Q9UK45
Validated Y2H
32296183
Intra
TCL1B O95988 LSM5 Homo sapiens Q9Y4Y9
Validated Y2H
32296183
Intra
TCL1B O95988 ZNF330 Homo sapiens Q9Y3S2
Y2H Prey Pooling
32296183
Intra
TCL1B O95988 ZNF330 Homo sapiens Q9Y3S2
Validated Y2H
32296183
Intra
TCL1B O95988 ZNF330 Homo sapiens Q9Y3S2
Y2H Array
32296183
Intra
TCL1B O95988 GLRX3 Homo sapiens O76003
Y2H Prey Pooling
32296183
Intra
TCL1B O95988 GLRX3 Homo sapiens O76003
Y2H Array
32296183
Intra
TCL1B O95988 SNRPG Homo sapiens P62308
Validated Y2H
32296183
Intra
TCL1B O95988 MARK1 Homo sapiens Q9P0L2
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Leukemia

  • Leukemias

  • Leukaemia, Unspecified, Without Mention Of Remission

  • Aleukemic Leukaemia

  • Chronic Leukaemia

  • Subacute Leukaemia

  • Leukaemia Disorder

  • Leukaemia Nos
Lymphoma

  • Lymphoid Cancer

  • Lymphomas

  • Lymphoid Cancers

  • Lymphoid Neoplasm

  • Lymphoma Nos

  • Nhl - [Non-Hodgkin Lymphoma]

  • Non-Hodgkin Lymphoma

  • Non-Hodgkin Lymphoma, Nos

  • Non-Hodgkin Malignant Lymphoma Nos
T-Cell Prolymphocytic Leukemia

  • T Cell Prolymphocytic Leukemia

  • Prolymphocytic Leukemia, T-Cell Type

  • T-Pll

  • T-Cell Chronic Lymphocytic Leukemia

  • Lymphocytic Leukemia T-Cell Chronic

  • Doid:0081042

  • Leukemia, T-Cell, Chronic

  • Prolymphocytic Leukaemia Of T-Cell Type Without Mention Of Remission
T-Cell Acute Lymphoblastic Leukemia

  • T-Cell Leukemia

  • Acute T Cell Leukemia

  • Precursor T Lymphoblastic Leukemia

  • Precursor T-Lymphoblastic Lymphoma/Leukemia

  • T Acute Lymphoblastic Leukemia

  • T-Cell Acute Lymphocytic Leukaemia

  • T-Cell Lymphoblastic Leukemia/Lymphoma

  • Leukemia T-Cell

  • Leukemia, T-Cell

  • Leukemia, Acute, Lymphoblastic, T-Cell

  • Leukemia, T-Cell Acute Lymphoblastic

  • Leukemia, Acute T-Cell

  • Precursor T-Cell Lymphoblastic Leukemia-Lymphoma

  • Precursor T-Cell Lymphoblastic Lymphoma

  • Precursor T Cell Lymphoblastic Leukemia/Lymphoblastic Lymphoma
Bn2 Diffuse Large B-Cell Lymphoma

  • Bn2 Dlbcl

  • Doid:0081064
Richter'S Syndrome

  • Richter Syndrome

  • Richter Transformation
Prolymphocytic Leukemia

  • Pll

  • Prolymphocytic Leukaemia

  • Leukemia Prolymphocytic

  • Leukemia, Prolymphocytic
Splenic Manifestation Of Leukemia

  • Splenic Leukemia
Mantle Cell Lymphoma

  • Lymphoma, Mantle Cell

  • Lcm

  • Mcl

  • Mantle Zone Lymphoma

  • Lymphoma Mantle-Cell

  • Lymphoma, Mantle-Cell

  • Malignant Lymphoma, Lymphocytic, Intermediate Differentiation, Diffuse

  • Malignant Lymphoma - Lymphocytic, Intermediate Differentiation

  • Diffuse Small Cleaved-Cell Lymphoma

  • Diffuse Small Cleaved Cell Malignant Lymphoma

  • Small Cleaved Cell Non-Hodgkin Lymphoma

  • Diffuse Non-Hodgkin Small Cleaved Cell Lymphoma

  • Malignant Lymphomatous Polyposis

  • Malignant Small Cell, Noncleaved, Diffuse Lymphoma

  • Malignant Undifferentiated Cell, Non-Burkitt Lymphoma

  • Cleaved Cell Lymphoma

  • Small Cell Mantle Cell Lymphoma

  • Small Cleaved Cell Malignant Lymphoma
Leukemia, Chronic Lymphocytic

  • Chronic Lymphocytic Leukemia

  • B-Cell Chronic Lymphocytic Leukemia

  • CLL

  • B-Cell Chronic Lymphoid Leukemia

  • Chronic Lymphatic Leukemia

  • Chronic Lymphocytic Leukaemia

  • Lymphoplasmacytic Leukemia

  • Small Lymphocytic Lymphoma

  • Leukemia, Chronic Lymphatic

  • B-Cell Chronic Lymphocytic Leukaemia

  • Chronic Lymphatic Leukaemia

  • Lymphoplasmacytic Leukaemia

  • B Cell Chronic Lymphocytic Leukemia

  • Chronic B-Cell Lymphocytic Leukemia

  • Leukemia, Lymphocytic, Chronic

  • B-Cll

  • Chronic Lymphoid Leukemia

  • Leukemia Lymphocytic Chronic

  • Lymphoma Small Lymphocytic

  • Leukemia, Lymphocytic, Chronic, B-Cell
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Nom du produit
Effect
Pureté
Rare Diseases
HY-RS14317 TCL1B Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta TCL1B VGNC VGNC:99736
Bos taurus TCL1B VGNC VGNC:99735
Others TCL1B NCBI