HDAC6-IN-63
HDAC6-IN-63 (Compound 7) is an orally active HDAC6 inhibitor with an IC50 of 145 nM. HDAC6-IN-63 inhibits the expression of Sp1 and RAD51, thereby inducing Caspase-dependent apoptosis. HDAC6-IN-63 has antitumor activity and sensitizes Etoposide (HY-13629) and Gemcitabine (HY-17026), promoting synergistic death of NSCLC cells through the inhibition of homologous recombination and non-homologous end joining (NHEJ) pathways involved in DNA DSB repair. HDAC6-IN-63 can be used for chemotherapy of cancers like NSCLC research.
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- Formule: C25H23N3O3S
- Masse moléculaire:445.53
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
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Activité biologique
|
HDAC6 145 nM (IC50) |
Caspase-9 |
Caspase-3 |
Caspase-7 |
HDAC1 4106 nM (IC50) |
HDAC4 1738 nM (IC50) |
Chemical Information
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Masse moléculaire 445.53
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Formule C25H23N3O3S
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SMILES
O=C(N(C(C1=CC=CC=C12)=O)CCC3=CC=CC=C3)N2CC(C=C4)=CC=C4NC(CS)=O
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
HDAC6-IN-63 Related Classifications
HY-178022 Related Classifications
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