Hirudin
Based on 4 publication(s) in Google Scholar
Hirudin is a thrombin inhibitor with blood anticoagulant property. Hirudin has potent anti-thrombotic, wound repair, anti-fibrosis, anti-tumor and anti-hyperuricemia effects. Hirudin also affects diabetic complications, cerebral hemorrhage, and others.
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- Pureté: 95.0%
- CAS No.: 8001-27-2
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Activité biologique
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Chemical Information
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Publications Citing Use of MedChemExpress (MCE) Hirudin
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Activité biologique
Hirudin inhibits the activity of thrombin, deprives the ability of thrombin to cleave fibrinogen, prevents the formation of fibrin and the cross-linking polymerization process of fibrin monomer in internal and external coagulation pathway[1]. Hirudin reduces cell apoptosis of human microvascular endothelial cells (HMVECs) and suppresses the expression of p-JAK2 via antagonizing thrombin[1]. Hirudin inhibits VEGF-Notch pathway and cell proliferation of HMVECs at high doses[1]. Hirudin (3-10 mg/mL) reverses the abnormal proliferation and fibrosis in HK-2 cells caused by TGF-β1[1]. Hirudin depresses the myocardial fibroblasts induced by angiotensin II by dose-dependently inhibits oxidative stress, regulates fibrosis-related factors, and represses the ERK1/2 pathway[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male balb/c mice with underwent unilateral ureteral ligation (UUO)[2]
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Dosage:10 and 15 mg/kg
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Administration:Oral gavage; 10 and 15 mg/kg, once daily for 21 days
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Result:Reduced renal damages and suppressed the upregulation of α-SMA, collagen deposition in UUO mice. Increased the level of fibrosis (collagen-I, FN, α-SMA), N-cad, slug and E-cad in UUO mice. Decreased the level of IL-1β, IL-6 and TNF-α, apoptosis of renal tubular cells in UUO mice. Decreased the expression of inflammatory factors, the occurrence of EMT, the incidence of fibrosis and the apoptosis of TGF-β-induced renal tubular epithelial cell.
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
Publications (4)
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Journal Impact Factor
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Most Recent
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J Interferon Cytokine Res
2025 Oct;45(10):335-343. PMID: 40916805 -
Acta Cir Bras
Hirudin inhibits ferroptosis to improve renal fibrosis by targeting the STAT3/NLRP3 signaling pathway. [Abstract]2025 Apr 28:40:e403325. PMID: 40298655 -
Biosci Biotechnol Biochem
Hirudin Alleviates Renal Fibrosis by Inducing Autophagy to Suppress NLRP3 Inflammasome Activation. [Abstract]2025 Jul 29:zbaf114. PMID: 40728927 -
Pureté et documentation
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Fiche technique (268 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Instruction de manipulation (2659 KB)
Références
[1]. Junren C,et al. Pharmacological Activities and Mechanisms of Hirudin and Its Derivatives - A Review. Front Pharmacol. 2021 Apr 16;12:660757. [Content Brief]
[2]. Xie Y, et al. Hirudin improves renal interstitial fibrosis by reducing renal tubule injury and inflammation in unilateral ureteral obstruction (UUO) mice. Int Immunopharmacol. 2020 Apr;81:106249. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Hirudin Related Classifications
HY-P2813 Related Classifications
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