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Cat. No.: HY-P990072

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Biologically Validated

Lipustobart

Name: Lipustobart
Brand: MedChemExpress
SKU: HY-P990072
Price: 280.00 USD
Availability: InStock
Rating: 5 (1 reviews)

(Synonyms: LZM-009)

Avis client

Based on 1 Customer Validation

Lipustobart (LZM-009) is a PD-1 inhibitor that binds to PD-1 and blocks the PD-1/PD-L1 interaction. Lipustobart also binds to FcRn and FcγRI. Lipustobart can be used in research on colon cancer.

Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.

Pureté : 99.9%
CAS No.: 2639481-06-2
Masse moléculaire:146.101 kDa

Stockage:

Shipping with dry ice

Please store the product under the recommended conditions in the Certificate of Analysis.

Lipustobart Chemical Structure

CAS No.: 2639481-06-2

Size

Prix

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* Veuillez sélectionner la quantité avant d'ajouter des articles.

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- Isotype
- Recommend Isotype Controls
- Species Reactivity
- IC₅₀ & Target
- In Vitro
- In Vivo
- Gene ID
- Accession
- Conjugated
- Reconsititution
- Format
- Application
- Verified Bioactivity
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

Isotype

Human IgG4 kappa

Recommend Isotype Controls

Human IgG4 (S228P) kappa, Isotype Control

Species Reactivity

Human

IC₅₀ & Target

^[1]

PD-1

PD-L1

FcRn

FcγRI

In Vitro

Immune Tolerance and ImmunosuppressionOthers

Immune Tolerance and Immunosuppression

Lipustobart (2.5 µg/mL for 2 h) binds human PD-1 and FcγRI/CD64^[1].
Lipustobart (100 nM for 24 h) blocks PD-1/PD-L1 signaling in Jurkat-Lucia TCR-hPD-1 reporter cells co-cultured with Raji-APC-hPD-L1 cells^[1].

Others

Lipustobart binds human FcRn at pH 6^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Anti-cancer

Lipustobart (1 mg/kg; i.v.; days 10 and 17 after tumor cell inoculation) inhibits tumor growth in the subcutaneous MC38 colon cancer model in hPD-1 transgenic mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Subcutaneous MC38 colon cancer model in hPD-1 transgenic mice^[1]
Dosage:

1 mg/kg
Administration:

i.v.; days 10 and 17 after tumor cell inoculation
Result:

Inhibited tumor growth, with 6 out of 9 subjects achieving complete remission.

Gene ID

5133 [NCBI]

Accession

Q15116

Conjugated

Unconjugated

Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.

Format

Human IgG4 kappa

Application

ELISA, FACS, Functional assay

Verified Bioactivity

Immobilized PD-1 Protein, Human (HEK293, His, HY-P7396) can bind Lipustobart. The EC₅₀ for this effect is 1.21 ng/mL.

Chemical Information

CAS No. 2639481-06-2
Appearance Liquid
Masse moléculaire 146.101 kDa
Color Colorless to light yellow
SMILES

[Lipustobart]
Synonyms

LZM-009
Livraison

Shipping with dry ice.
Formulation

Please refer to the lot-specific COA for specific buffer information.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (271 KB)
SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Inhibitory Antibodies User Guide (603 KB)

Références

[1]. Oelgarth N, et al. Anti-PD1-IL18 immunoconjugate promotes effector T cell-mediated antitumor immunity. J Immunother Cancer. 2026 Jul 14;14(7):e015090.

[2]. International Nonproprietary Names for Pharmaceutical Substances (INN). WHO Drug Information, Vol. 36, No. 2, 2022.

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

MOQ

Minimum order quantity

100 mg

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Activité biologique
- Description
- Isotype
- Recommend Isotype Controls
- Species Reactivity
- IC₅₀ & Target
- In Vitro
- In Vivo
- Gene ID
- Accession
- Conjugated
- Reconsititution
- Format
- Application
- Biological Activity
Chemical Information
Pureté et documentation
Références

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Lipustobart