MK-0493
Based on 1 Customer Validation
MK-0493 is an orally active melanocortin-4 receptor (MC4R) agonist. MK-0493 reduces food intake, suppresses weight gain, elevates blood pressure at high doses, and exhibits preclinical erectile regulatory activity. MK-0493 can be used in research related to obesity.
Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.
- Pureté: 98.19%
- CAS No.: 455956-93-1
- Formule: C30H38ClF2N3O2
- Masse moléculaire:546.09
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Stockage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
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Solvant et solubilité
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
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MC4R |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
| NCT Number | Sponsor | Condition | Start Date |
Phase
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|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS No. 455956-93-1
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Appearance Solid
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Masse moléculaire 546.09
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Formule C30H38ClF2N3O2
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Color White to light yellow
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SMILES
CC(N[C@@H](C)C1=CC(Cl)=CC=C1C2CCN(CC2)C([C@@H]3CN(C[C@H]3C4=CC=C(C=C4F)F)C(C)(C)C)=O)=O
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvant et solubilité
DMSO : 100 mg/mL (183.12 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureté et documentation
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Fiche technique (274 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Instruction de manipulation (2659 KB)
Références
[1]. Krishna R, etal. Potent and selective agonism of the melanocortin receptor 4 with MK-0493 does not induce weight loss in obese human subjects: energy intake predicts lack of weight loss efficacy. Clin Pharmacol Ther. 2009 Dec;86(6):659-66. [Content Brief]
[2]. Krishna R, et al. Lack of erectogenic activity of a novel selective melanocortin-4 receptor agonist in a clinical experimental model. J Clin Pharmacol. 2008 Oct;48(10):1237-41. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.8312 mL | 9.1560 mL | 18.3120 mL | 45.7800 mL |
| 5 mM | 0.3662 mL | 1.8312 mL | 3.6624 mL | 9.1560 mL | |
| 10 mM | 0.1831 mL | 0.9156 mL | 1.8312 mL | 4.5780 mL | |
| 15 mM | 0.1221 mL | 0.6104 mL | 1.2208 mL | 3.0520 mL | |
| 20 mM | 0.0916 mL | 0.4578 mL | 0.9156 mL | 2.2890 mL | |
| 25 mM | 0.0732 mL | 0.3662 mL | 0.7325 mL | 1.8312 mL | |
| 30 mM | 0.0610 mL | 0.3052 mL | 0.6104 mL | 1.5260 mL | |
| 40 mM | 0.0458 mL | 0.2289 mL | 0.4578 mL | 1.1445 mL | |
| 50 mM | 0.0366 mL | 0.1831 mL | 0.3662 mL | 0.9156 mL | |
| 60 mM | 0.0305 mL | 0.1526 mL | 0.3052 mL | 0.7630 mL | |
| 80 mM | 0.0229 mL | 0.1144 mL | 0.2289 mL | 0.5722 mL | |
| 100 mM | 0.0183 mL | 0.0916 mL | 0.1831 mL | 0.4578 mL |
MK-0493 Related Classifications
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