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Cat. No.: HY-164381

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Omoconazole

Omoconazole is an imidazole-derived azole antifungal agent. Omoconazole exhibits broad-spectrum in vitro activity against dermatophytes, yeasts, and dimorphic fungi, exerting fungistatic effects at low concentrations and fungicidal effects at high concentrations. Omoconazole accumulates in the skin, binds to keratin, and is slowly transferred from the stratum corneum to the viable epidermis. Omoconazole inhibits the growth of dermatophytes, impairs daughter cell separation in Candida albicans, induces cell wall thickening, disrupts intracellular cytoplasmic organelles, and leads to cell death. Omoconazole is used in studies related to dermatophytosis and superficial fungal infections.

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CAS No.: 74512-12-2
Formule: C₂₀H₁₇Cl₃N₂O₂
Masse moléculaire:423.72

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Omoconazole Chemical Structure

CAS No.: 74512-12-2

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- In Vitro
- In Vivo
Chemical Information
Pureté et documentation
Références
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Activité biologique

Description

In Vitro

Omoconazole (0.4-40 μg/mL; 8-24 h) induces concentration- and time-dependent morphological and ultrastructural changes in Candida albicans TIMM 0146, exerting a fungistatic effect at medium and low concentrations (characterized by cell aggregation, cell wall thickening, and Golgi-like structure formation) and a fungicidal effect at high concentrations (characterized by organelle destruction and cytolysis)^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Omoconazole cream (0.25-2.0% cream; topical administration; once daily; for 14 days) exhibits dose-dependent efficacy against dermatophytosis in guinea pigs, and medium to high concentrations achieve complete resolution of symptoms and complete fungal eradication^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Hartley (female, 300-350 g, dermatophytosis model via Trichophyton mentagrophytes conidial suspension inoculation on abraded shaved back skin)^[1]
Dosage:

0.25% cream; 0.5% cream; 1.0% cream; 2.0% cream
Administration:

topical; once daily; 14 days
Result:

Significantly reduced lesional symptoms starting on days 8-10 post-infection with all tested concentrations.
Achieved almost complete symptomatological cure with 1.0% and 2.0% creams by the end of 14-day treatment.
Resulted in a mean of 8.3 culture-positive skin blocks in 0.25% cream-treated animals.
Resulted in a mean of 1.5 culture-positive skin blocks in 0.5% cream-treated animals.
Resulted in 0 culture-positive skin blocks in 1.0% and 2.0% cream-treated animals, indicating complete inhibition of fungal growth.

Chemical Information

CAS No. 74512-12-2
Masse moléculaire 423.72
Formule C₂₀H₁₇Cl₃N₂O₂
SMILES

C/C(N1C=CN=C1)=C(C2=C(C=C(C=C2)Cl)Cl)/OCCOC3=CC=C(C=C3)Cl
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Instruction de manipulation (2659 KB)

Références

[1]. Hashiguchi T, et al. Study of the effective dose of a topical antifungal agent, omoconazole nitrate, on the basis of percutaneous pharmacokinetics in guinea-pigs and mice. The Journal of pharmacy and pharmacology. 1997 Aug;49(8):757-61. [Content Brief]

[2]. Nishiyama Y, et al. Ultrastructural alterations of Candida albicans induced by a new imidazole antimycotic omoconazole nitrate. Microbiology and immunology. 1997;41(5):395-402.

[3]. Babazadeh-Qazijahani M, et al. Imidazolylchromanones containing non-benzylic oxime ethers: synthesis and molecular modeling study of new azole antifungals selective against Cryptococcus gattii. European journal of medicinal chemistry. 2014 Apr 09;76:264-73.

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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